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Q3K3G9 (PNP_STRA1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyribonucleotide nucleotidyltransferase

EC=2.7.7.8
Alternative name(s):
Polynucleotide phosphorylase
Short name=PNPase
Gene names
Name:pnp
Ordered Locus Names:SAK_0266
OrganismStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]
Taxonomic identifier205921 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity. HAMAP-Rule MF_01595

Catalytic activity

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. HAMAP-Rule MF_01595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01595

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01595.

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Polyribonucleotide nucleotidyltransferase HAMAP-Rule MF_01595
PRO_0000329864

Regions

Domain556 – 61560KH
Domain625 – 69369S1 motif

Sites

Metal binding4891Magnesium By similarity
Metal binding4951Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K3G9 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 558414425A1FAE61

FASTA70977,210
        10         20         30         40         50         60 
MSKQVFEMIF AGKKLVVETG QVAKQANGSV VVRYGDSTVL TAAVMSKKMS TGDFFPLQVN 

        70         80         90        100        110        120 
YEEKMYAAGK FPGGFNKREG RPSTDATLTA RLIDRPIRPM FAEGFRNEVQ VINTVLSFDE 

       130        140        150        160        170        180 
NASAPMAAMF GSSLALSISD IPFNGPIAGV QVAYVDGNFI INPTAQEQEA SALELTVAGT 

       190        200        210        220        230        240 
KEAINMVESG AKELSEEIML EALLKGHEAV CELIAFQEEI VTAIGKEKAE VELLQVDPEL 

       250        260        270        280        290        300 
QAEIIATHNI ALQAAVQVEE KKAREAATEA VKEVVIGEYE ARYAEHEEYD RIMRDVAEIL 

       310        320        330        340        350        360 
EQMEHAEVRR LITEDKIRPD GRRVDEIRPL DAEIDFLPQV HGSGLFTRGQ TQALSVLTLA 

       370        380        390        400        410        420 
PMGEAQIIDG LTPEYKKRFM HHYNFPQYSV GETGRYGAAG RREIGHGALG ERALEQVLPS 

       430        440        450        460        470        480 
LEEFPYAIRL VAEVLESNGS SSQASICAGT LALMAGGVPI KAPVAGIAMG LISDGTNYTV 

       490        500        510        520        530        540 
LTDIQGLEDH FGDMDFKVAG TREGITALQM DIKIEGITPQ ILEEALAQAK KARFEILDVL 

       550        560        570        580        590        600 
HGAIAEPRPQ LAPTAPKIDM IKIDVDKIKV VIGKGGETID KIIAETGVKI DIDEEGNVSI 

       610        620        630        640        650        660 
FSSDQAAIDR TKDIIASLVR EAKVGEVYHA KVVRIEKFGA FVNLFDKTDA LVHISEIAWT 

       670        680        690        700 
RTANVADVLE IGEEVDVKVI KIDDKGRVDA SMKALLPRPP KADNPKKES 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000114 Genomic DNA. Translation: ABA45814.1.
RefSeqYP_328934.1. NC_007432.1.

3D structure databases

ProteinModelPortalQ3K3G9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205921.SAK_0266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA45814; ABA45814; SAK_0266.
GeneID3686032.
KEGGsak:SAK_0266.
PATRIC19631738. VBIStrAga82541_0211.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1185.
HOGENOMHOG000218326.
KOK00962.
OMALDFFPLT.
OrthoDBEOG6WT8CC.
ProtClustDBPRK11824.

Enzyme and pathway databases

BioCycSAGA205921:GHD7-266-MONOMER.

Family and domain databases

Gene3D1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPMF_01595. PNPase.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERPTHR11252. PTHR11252. 1 hit.
PfamPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFPIRSF005499. PNPase. 1 hit.
SMARTSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsTIGR03591. polynuc_phos. 1 hit.
PROSITEPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNP_STRA1
AccessionPrimary (citable) accession number: Q3K3G9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families