Q3K2Y2 (G6PI_STRA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	SAK_0475

Organism

Streptococcus agalactiae serotype Ia [Complete proteome] [HAMAP]

Taxonomic identifier

355315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000230938
Sites
	Active site	291	1	Proton donor By similarity
	Active site	312	1	By similarity
	Active site	426	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3K2Y2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 5199E72DE0CDCE1B	FASTA	449	49,585
	10 20 30 40 50 60 MTHITFDYSK VLGQFVGEHE LDYLQPQVSA ADAFLRQGTG PGSDFLGWMD LPENYDKEEF 70 80 90 100 110 120 SRIQKAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNNHF ANLQTAEERK APQILYAGNS 130 140 150 160 170 180 ISSTYLADLV EYVQDKEFSV NVISKSGTTT EPAIAFRVFK ELLVKKYGQE EANKRIYATT 190 200 210 220 230 240 DKVKGAVKVE ADANNWETFV VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD 250 260 270 280 290 300 LSSDKISENI AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 310 320 330 340 350 360 YPTSANFSTD LHSLGQFIQE GYRNLFETVV RVEKPRKNVT IPELTEDLDG LGYLQGKDVD 370 380 390 400 410 420 FVNKKATDGV LLAHTDGGVP NMFVTLPTQD AYTLGYTIYF FELAIGLSGY LNSVNPFDQP 430 440 GVEAYKRNMF ALLGKPGFEE LSAELNARL

References

[1]

"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed: 16172379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700 / Serotype Ia.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000114 Genomic DNA. Translation: ABA44794.1.
RefSeq	YP_329121.1. NC_007432.1.
3D structure databases
ProteinModelPortal	Q3K2Y2.
SMR	Q3K2Y2. Positions 4-449.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000005608; EBSTRP00000005381; EBSTRG00000005608.
GeneID	3686538.
GenomeReviews	Gene locus SAK_0475 in contig CP000114_GR.
KEGG	sak:SAK_0475.
PATRIC	19632166. VBIStrAga82541_0403.
TIGR	SAK_0475.
Phylogenomic databases
GeneTree	EBGT00050000026848.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	SAGA205921:SAK_0475-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_STRA1

Accession

Primary (citable) accession number: Q3K2Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program