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Q3K2Y2

- G6PI_STRA1

UniProt

Q3K2Y2 - G6PI_STRA1

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorUniRule annotation
    Active sitei312 – 3121UniRule annotation
    Active sitei426 – 4261UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSAGA205921:GHD7-475-MONOMER.
    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:SAK_0475
    OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    Taxonomic identifieri205921 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002701: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000230938Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205921.SAK_0475.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K2Y2.
    SMRiQ3K2Y2. Positions 4-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiKNMTHIT.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3K2Y2-1 [UniParc]FASTAAdd to Basket

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    MTHITFDYSK VLGQFVGEHE LDYLQPQVSA ADAFLRQGTG PGSDFLGWMD    50
    LPENYDKEEF SRIQKAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNNHF 100
    ANLQTAEERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT 150
    EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV 200
    VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI 250
    AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 300
    YPTSANFSTD LHSLGQFIQE GYRNLFETVV RVEKPRKNVT IPELTEDLDG 350
    LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPTQD AYTLGYTIYF 400
    FELAIGLSGY LNSVNPFDQP GVEAYKRNMF ALLGKPGFEE LSAELNARL 449
    Length:449
    Mass (Da):49,585
    Last modified:November 8, 2005 - v1
    Checksum:i5199E72DE0CDCE1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000114 Genomic DNA. Translation: ABA44794.1.
    RefSeqiYP_329121.1. NC_007432.1.

    Genome annotation databases

    EnsemblBacteriaiABA44794; ABA44794; SAK_0475.
    GeneIDi3686538.
    KEGGisak:SAK_0475.
    PATRICi19632166. VBIStrAga82541_0403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000114 Genomic DNA. Translation: ABA44794.1 .
    RefSeqi YP_329121.1. NC_007432.1.

    3D structure databases

    ProteinModelPortali Q3K2Y2.
    SMRi Q3K2Y2. Positions 4-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205921.SAK_0475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA44794 ; ABA44794 ; SAK_0475 .
    GeneIDi 3686538.
    KEGGi sak:SAK_0475.
    PATRICi 19632166. VBIStrAga82541_0403.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi KNMTHIT.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .
    BioCyci SAGA205921:GHD7-475-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'."
      Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P.
      , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M.
      Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27591 / A909 / CDC SS700.

    Entry informationi

    Entry nameiG6PI_STRA1
    AccessioniPrimary (citable) accession number: Q3K2Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3