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Protein

Uronate isomerase

Gene

uxaC

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.UniRule annotation
D-galacturonate = D-tagaturonate.UniRule annotation

Pathway: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciSAGA205921:GHD7-828-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomeraseUniRule annotation (EC:5.3.1.12UniRule annotation)
Alternative name(s):
Glucuronate isomeraseUniRule annotation
Uronic isomeraseUniRule annotation
Gene namesi
Name:uxaCUniRule annotation
Ordered Locus Names:SAK_0827
OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Taxonomic identifieri205921 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Uronate isomerasePRO_1000044780Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ3K204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uronate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1904.
HOGENOMiHOG000224075.
KOiK01812.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3K204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFNTETFML KNQAALQLYE EVKRQPIFDY HCHLDPKDIF EDRIFDNIVD
60 70 80 90 100
LWLGGDHYKW RLMRANGISE AEITGPASNL EKFKAFARTL ERAYGNPVYH
110 120 130 140 150
WSAMELKNVF GVNEILTESN AEEIYHRLNH FLKEHKINPR RLIADSKVMF
160 170 180 190 200
IGTTDHPLDT LEWHKKLAAD ESFKTVVAPT FRPDEAFIEH RHFVDFITKL
210 220 230 240 250
GDITQKEITD FSTFIAAMEE RIAYFAQNGC RASDISFTEI VFEQTDELEL
260 270 280 290 300
NDLFNKVCEG YIPNQSEISK WQTAVFMELC RLYKKYGFVT QVHFGALRNN
310 320 330 340 350
HSTIFEKLGA DVGVDSLGDQ VALTVNMNSL LDSLVKKDSL PKMIWYNLNP
360 370 380 390 400
AYNIAVANTL ANFQANELGV RSYLQFGAGW WFADTKLGMI SQMNALAEQG
410 420 430 440 450
MLANFIGMLT DSRSFLSYQR HDYFRRILCT YLGEWIEEGE VPEDYQALGS
460
MAKDIAYQNA VNYFKN
Length:466
Mass (Da):53,811
Last modified:November 8, 2005 - v1
Checksum:iA5BA062EFBDA316D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA. Translation: ABA44392.1.
RefSeqiWP_000143795.1. NC_007432.1.
YP_329449.1. NC_007432.1.

Genome annotation databases

EnsemblBacteriaiABA44392; ABA44392; SAK_0827.
KEGGisak:SAK_0827.
PATRICi19632917. VBIStrAga82541_0768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA. Translation: ABA44392.1.
RefSeqiWP_000143795.1. NC_007432.1.
YP_329449.1. NC_007432.1.

3D structure databases

ProteinModelPortaliQ3K204.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA44392; ABA44392; SAK_0827.
KEGGisak:SAK_0827.
PATRICi19632917. VBIStrAga82541_0768.

Phylogenomic databases

eggNOGiCOG1904.
HOGENOMiHOG000224075.
KOiK01812.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciSAGA205921:GHD7-828-MONOMER.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'."
    Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P.
    , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M.
    Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27591 / A909 / CDC SS700.

Entry informationi

Entry nameiUXAC_STRA1
AccessioniPrimary (citable) accession number: Q3K204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.