Q3K204 (UXAC_STRA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uronate isomerase
EC=5.3.1.12

Alternative name(s):
Glucuronate isomerase
Uronic isomerase

Gene names

Name:	uxaC
Ordered Locus Names:	SAK_0827

Organism

Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]

Taxonomic identifier

205921 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus agalactiae › Streptococcus agalactiae serogroup Ia

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucuronate = D-fructuronate. HAMAP-Rule MF_00675 D-galacturonate = D-tagaturonate. HAMAP-Rule MF_00675
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00675
Sequence similarities	Belongs to the uronate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glucuronate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Uronate isomerase HAMAP-Rule MF_00675		PRO_1000044780

Sequences

	Sequence		Length	Mass (Da)
	Q3K204 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: A5BA062EFBDA316D	FASTA	466	53,811
	10 20 30 40 50 60 MTFNTETFML KNQAALQLYE EVKRQPIFDY HCHLDPKDIF EDRIFDNIVD LWLGGDHYKW 70 80 90 100 110 120 RLMRANGISE AEITGPASNL EKFKAFARTL ERAYGNPVYH WSAMELKNVF GVNEILTESN 130 140 150 160 170 180 AEEIYHRLNH FLKEHKINPR RLIADSKVMF IGTTDHPLDT LEWHKKLAAD ESFKTVVAPT 190 200 210 220 230 240 FRPDEAFIEH RHFVDFITKL GDITQKEITD FSTFIAAMEE RIAYFAQNGC RASDISFTEI 250 260 270 280 290 300 VFEQTDELEL NDLFNKVCEG YIPNQSEISK WQTAVFMELC RLYKKYGFVT QVHFGALRNN 310 320 330 340 350 360 HSTIFEKLGA DVGVDSLGDQ VALTVNMNSL LDSLVKKDSL PKMIWYNLNP AYNIAVANTL 370 380 390 400 410 420 ANFQANELGV RSYLQFGAGW WFADTKLGMI SQMNALAEQG MLANFIGMLT DSRSFLSYQR 430 440 450 460 HDYFRRILCT YLGEWIEEGE VPEDYQALGS MAKDIAYQNA VNYFKN

References

[1]

"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000114 Genomic DNA. Translation: ABA44392.1.
RefSeq	YP_329449.1. NC_007432.1.
3D structure databases
ProteinModelPortal	Q3K204.
ModBase	Search...
Protein-protein interaction databases
STRING	205921.SAK_0827.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA44392; ABA44392; SAK_0827.
GeneID	3685087.
KEGG	sak:SAK_0827.
PATRIC	19632917. VBIStrAga82541_0768.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1904.
HOGENOM	HOG000224075.
KO	K01812.
OMA	WIEEGEV.
ProtClustDB	PRK02925.
Enzyme and pathway databases
BioCyc	SAGA205921:GHD7-843-MONOMER.
UniPathway	UPA00246.
Family and domain databases
Gene3D	1.10.2020.10. 1 hit.
HAMAP	MF_00675. UxaC.
InterPro	IPR003766. Uronate_isomerase. IPR023177. Uronate_isomerase_dom2. [Graphical view]
Pfam	PF02614. UxaC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAC_STRA1

Accession

Primary (citable) accession number: Q3K204

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program