Reviewed, UniProtKB/Swiss-Prot Q3K203 (UXUA_STRA1)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	SAK_0828

Organism

Streptococcus agalactiae serotype Ia [Complete proteome] [HAMAP]

Taxonomic identifier

355315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Mannonate dehydratase HAMAP MF_00106		PRO_0000231059

Sequences

	Sequence		Length	Mass (Da)
	Q3K203-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 2D124F68B7D8C5CB	FASTA	348	39,277
	10 20 30 40 50 60 MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK EKVEAAGLKI 70 80 90 100 110 120 SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT ICYNFMPVFD WTRTDLAYQY 130 140 150 160 170 180 PDGSTALIFD ETVSKKMDPV NGELSLPGWD ASYSKEEMKA IMDAYAEIDE EKLWENLTYF 190 200 210 220 230 240 IKRIIPEAEA VGVKMAIHPD DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY 250 260 270 280 290 300 ASDPQNDVLE ISRRAFELER VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE 310 320 330 340 FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYLSGLY EAVIKGSK

References

[1]

"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed: 16172379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700 / Serotype Ia.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000114 Genomic DNA. Translation: ABA45816.1.
RefSeq	YP_329450.1.
3D structure databases
SMR	Q3K203. Positions 1-345.
ModBase	Search...
Genome annotation databases
GeneID	3686034.
GenomeReviews	Gene locus SAK_0828 in contig CP000114_GR.
KEGG	sak:SAK_0828.
TIGR	SAK_0828.
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
Enzyme and pathway databases
BioCyc	SAGA205921:SAK_0828-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_STRA1

Accession

Primary (citable) accession number: Q3K203

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)