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Q3K1L7 (THIM_STRA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:SAK_0964
OrganismStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]
Taxonomic identifier205921 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021537

Sites

Binding site381Substrate; via amide nitrogen By similarity
Binding site1141ATP By similarity
Binding site1591ATP By similarity
Binding site1861Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K1L7 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 1A1EC368FA2190D2

FASTA25627,014
        10         20         30         40         50         60 
MYLEQLKEVN PLTICITNNV VKNFTANGLL ALGASPAMSE CIEDLEDLLK VADALLINIG 

        70         80         90        100        110        120 
TLTKESWQLY QEAIKIANKN QVPVVLDPVA AGASRFRLEV SLDLLKNYSI SLLRGNGSEI 

       130        140        150        160        170        180 
AALIGEKQAS KGADGGKVAD LESIAVKANQ VFDVPVVVTG ETDAIAVRGE VRLLQNGSPL 

       190        200        210        220        230        240 
MPLVTGTGCL LGAVLAAFIG SSDRSDDLAC LTEAMTVYNV AGEIAEKVAK GKGVGSFQVA 

       250 
FLDALSQMKS EMIMDK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000114 Genomic DNA. Translation: ABA45778.1.
RefSeqYP_329586.1. NC_007432.1.

3D structure databases

ProteinModelPortalQ3K1L7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205921.SAK_0964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA45778; ABA45778; SAK_0964.
GeneID3685160.
KEGGsak:SAK_0964.
PATRIC19633193. VBIStrAga82541_0906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycSAGA205921:GHD7-965-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_STRA1
AccessionPrimary (citable) accession number: Q3K1L7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways