Q3K1K2 (GLGA_STRA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycogen synthase
EC=2.4.1.21

Alternative name(s):
Starch [bacterial glycogen] synthase

Gene names

Name:	glgA
Ordered Locus Names:	SAK_0979

Organism

Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]

Taxonomic identifier

205921 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus agalactiae › Streptococcus agalactiae serogroup Ia

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes alpha-1,4-glucan chains using ADP-glucose By similarity. HAMAP-Rule MF_00484
Catalytic activity	ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1). HAMAP-Rule MF_00484
Pathway	Glycan biosynthesis; glycogen biosynthesis. HAMAP-Rule MF_00484
Sequence similarities	Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycogen biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	starch synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Glycogen synthase HAMAP-Rule MF_00484		PRO_0000230266
Sites
	Binding site	15	1	ADP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3K1K2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 2E0F259CE9F4CF8D	FASTA	476	54,514
	10 20 30 40 50 60 MKIMFVAAEG APFAKTGGLG DVIGALPKSL SKKGHDVAVV MPYYDMVDQK FGDQIENLMY 70 80 90 100 110 120 FYTDVGWRHQ YVGVKRLSQD NVTFYFIDNQ YYFYRGHVYG DWDDGERFAY FQLAALELME 130 140 150 160 170 180 KIDFIPDVLH VHDYHTAMIP FLLKEKYHWI QAYNNIRAVF TIHNIEFQGQ FGPEMLGDLF 190 200 210 220 230 240 GVGAERYEDG TLRWNNCLNW MKAAILYSDR VTTVSPSYAN EIKTPEFGKG LDQIMRMEAG 250 260 270 280 290 300 KLSGIVNGID SDLLNPETDA FLPYHFSKSN LEGKIKNKLA LQENLGLPQD KNVPLIGIVS 310 320 330 340 350 360 RLTDQKGFDI IASELDNMLQ QDIQMVILGT GYHHFEETFS YFASRYPEKL SANITFDLRL 370 380 390 400 410 420 AQQIYAASDI FMMPSAFEPC GLSQMMAMRY GSLPLVHEVG GLKDTVVAFN QFDGSGTGFS 430 440 450 460 470 FNHFSGYWLM QTLKLALEVY NDYPEAWKKL QWQAMSKDFS WDTACVAYEQ LYQQLQ

References

[1]

"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000114 Genomic DNA. Translation: ABA45078.1.
RefSeq	YP_329601.1. NC_007432.1.
3D structure databases
ProteinModelPortal	Q3K1K2.
ModBase	Search...
Protein-protein interaction databases
STRING	205921.SAK_0979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA45078; ABA45078; SAK_0979.
GeneID	3685649.
KEGG	sak:SAK_0979.
PATRIC	19633223. VBIStrAga82541_0921.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0297.
HOGENOM	HOG000294940.
KO	K00703.
OMA	ADVIMVP.
ProtClustDB	PRK00654.
Enzyme and pathway databases
BioCyc	SAGA205921:GHD7-995-MONOMER.
UniPathway	UPA00164.
Family and domain databases
HAMAP	MF_00484. Glycogen_synth.
InterPro	IPR001296. Glyco_trans_1. IPR011835. Glycogen/starch_synth. IPR013534. Starch_synth_cat_dom. [Graphical view]
Pfam	PF08323. Glyco_transf_5. 1 hit. PF00534. Glycos_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR02095. glgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLGA_STRA1

Accession

Primary (citable) accession number: Q3K1K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program