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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA205921:G1G54-1176-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SAK_1144
OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Taxonomic identifieri205921 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005461 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiQ3K138

Structurei

3D structure databases

ProteinModelPortaliQ3K138
SMRiQ3K138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3K138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VALKPIAEIV EQVGIGFDDI ELYGKYKAKL SFDKIEAVRS
60 70 80 90 100
QKVGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ
160 170 180 190 200
GNELDIDQRR VIWKRVVDLN DRALRQVIVG LGSPVNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DLSDLKKRLS NIVVAYSRDR KPIYVKDLKI EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYVVTEAG
310 320 330 340 350
FGADLGAEKF LDIKTPNLPT SPDAIVIVAT LRALKMHGGV SKEDLSQENV
360 370 380 390 400
EAVKRGFTNL ERHVNNMRQY GVPVVVAINQ FTADTESEIA TLKTLCSNID
410 420 430 440 450
VAVELASVWE DGADGGLELA QTVANVIETQ SSNYKRLYND ADTIEEKIKK
460 470 480 490 500
IVTKIYGGNK VHFGPKAQIQ LKEFSDNGWD KMPICMAKTQ YSFSDNPNLL
510 520 530 540 550
GAPTDFDITV REFVPKTGAG FIVALTGDVL TMPGLPKKPA ALNMDVLEDG

TAIGLF
Length:556
Mass (Da):59,886
Last modified:November 8, 2005 - v1
Checksum:i084FCE1B69A53691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA Translation: ABA44625.1
RefSeqiWP_000845309.1, NC_007432.1

Genome annotation databases

EnsemblBacteriaiABA44625; ABA44625; SAK_1144
KEGGisak:SAK_1144

Similar proteinsi

Entry informationi

Entry nameiFTHS_STRA1
AccessioniPrimary (citable) accession number: Q3K138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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