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Protein
Submitted name:

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: InterPro
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BioCyciSAGA205921:GHD7-1199-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseImported
Gene namesi
Name:folKImported
Ordered Locus Names:SAK_1198Imported
OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)Imported
Taxonomic identifieri205921 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002701: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi205921.SAK_1198.

Structurei

3D structure databases

ProteinModelPortaliQ3K0Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000217741.
KOiK00950.
OMAiIENKMGR.
OrthoDBiEOG6XHC8G.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3K0Y4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTVYLSLGS NIGDRETFLK QALFSIDHLQ KTKVAQISAI YETAAWGNTN
60 70 80 90 100
QEDFFNICCQ VETDLAPFEL LDYCQEIEKR LKRVRHEHWG PRTIDIDILL
110 120 130 140 150
FGNQVINQED LVVPHPYMTK RAFVLVPLLE IAPQLSLPNG SKLEDYLEKL
160
NLGEVHYLKP VE
Length:162
Mass (Da):18,659
Last modified:November 8, 2005 - v1
Checksum:i55E3E2DFF2D22C9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA. Translation: ABA45144.1.
RefSeqiYP_329819.1. NC_007432.1.

Genome annotation databases

EnsemblBacteriaiABA45144; ABA45144; SAK_1198.
GeneIDi3685774.
KEGGisak:SAK_1198.
PATRICi19633663. VBIStrAga82541_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA. Translation: ABA45144.1.
RefSeqiYP_329819.1. NC_007432.1.

3D structure databases

ProteinModelPortaliQ3K0Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205921.SAK_1198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA45144; ABA45144; SAK_1198.
GeneIDi3685774.
KEGGisak:SAK_1198.
PATRICi19633663. VBIStrAga82541_1141.

Phylogenomic databases

HOGENOMiHOG000217741.
KOiK00950.
OMAiIENKMGR.
OrthoDBiEOG6XHC8G.

Enzyme and pathway databases

BioCyciSAGA205921:GHD7-1199-MONOMER.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'."
    Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., Deboy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit Y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P.
    , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M.
    Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27591 / A909 / CDC SS700Imported.

Entry informationi

Entry nameiQ3K0Y4_STRA1
AccessioniPrimary (citable) accession number: Q3K0Y4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.