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Q3K0Y1 (GCH1_STRA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:SAK_1201
OrganismStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]
Taxonomic identifier205921 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043744

Sites

Metal binding761Zinc By similarity
Metal binding791Zinc By similarity
Metal binding1481Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K0Y1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 6732F6FD6D937254

FASTA18721,259
        10         20         30         40         50         60 
MPNQEKMEKA IYQFLEALGE NPDREGLKDT PKRVAKMYIE MFSGLNQDPK EQFTAVFSEN 

        70         80         90        100        110        120 
HEEVVIVKDI PFYSMCEHHL VPFYGKAHIA YLPNDGRVTG LSKLARAVEV ASKRPQLQER 

       130        140        150        160        170        180 
LTAQVAQALE DALAPKGIFV MIEAEHMCMT MRGIKKPGSK TITTVARGLY KDDRYERQEI 


LSLIQKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000114 Genomic DNA. Translation: ABA45773.1.
RefSeqYP_329822.1. NC_007432.1.

3D structure databases

ProteinModelPortalQ3K0Y1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205921.SAK_1201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA45773; ABA45773; SAK_1201.
GeneID3685155.
KEGGsak:SAK_1201.
PATRIC19633669. VBIStrAga82541_1144.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMARKPGAVT.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycSAGA205921:GHD7-1202-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_STRA1
AccessionPrimary (citable) accession number: Q3K0Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways