Reviewed, UniProtKB/Swiss-Prot Q3K0S8 (CPSB_STRA1)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase cpsB
    EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	cpsIaB
Ordered Locus Names:	SAK_1261

Organism

Streptococcus agalactiae serotype Ia [Complete proteome] [HAMAP]

Taxonomic identifier

355315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the cpsB/capC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Tyrosine-protein phosphatase cpsB		PRO_0000057888

Sequences

	Sequence		Length	Mass (Da)
	Q3K0S8-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 319CA48CCB310123	FASTA	243	28,600
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS 70 80 90 100 110 120 IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT 130 140 150 160 170 180 ALSNVLMLGI TPVVAHIERY NALENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF 190 200 210 220 230 240 KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of type-specific capsular polysaccharide biosynthesis genes of Streptococcus agalactiae type Ia." Yamamoto S., Miyake K., Koike Y., Watanabe M., Machida Y., Ohta M., Iijima S. J. Bacteriol. 181:5176-5184(1999) [PubMed: 10464185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: OI1 / Serotype Ia.
[2]	"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed: 16172379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700 / Serotype Ia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB028896 Genomic DNA. Translation: BAA82276.1. CP000114 Genomic DNA. Translation: ABA46124.1.
RefSeq	YP_329875.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3686665.
GenomeReviews	Gene locus SAK_1261 in contig CP000114_GR.
KEGG	sak:SAK_1261.
TIGR	SAK_1261.
Phylogenomic databases
HOGENOM	Q3K0S8.
OMA	ITPVIAH.
Enzyme and pathway databases
BioCyc	SAGA205921:SAK_1261-MON.
Family and domain databases
InterPro	IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view]
Pfam	PF02811. PHP. 1 hit. [Graphical view]
PIRSF	PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSB_STRA1

Accession

Primary (citable) accession number: Q3K0S8
Secondary accession number(s): P0A365, Q9S0S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)