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Q3K0S8

- CPSB_STRA1

UniProt

Q3K0S8 - CPSB_STRA1

Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. manganese ion binding Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    BioCyciSAGA205921:GHD7-1262-MONOMER.
    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
    Gene namesi
    Name:cpsB
    Synonyms:cpsIaB
    Ordered Locus Names:SAK_1261
    OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    Taxonomic identifieri205921 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002701: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057888Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205921.SAK_1261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K0S8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsB/CapC family.Curated

    Phylogenomic databases

    eggNOGiCOG4464.
    HOGENOMiHOG000007624.
    KOiK01104.
    OMAiTPHTLNG.
    OrthoDBiEOG6PKFDD.

    Family and domain databases

    InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view]
    PfamiPF02811. PHP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3K0S8-1 [UniParc]FASTAAdd to Basket

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    MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET    50
    PEDIIFKNFS IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN 100
    NTKFALIEFS MQTSWKDIHT ALSNVLMLGI TPVVAHIERY NALENQKERV 150
    KEIINMGCYT QINSSHILKQ KLFNDKHKRF KKRARYFLEE NLVHFVASDM 200
    HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI 243
    Length:243
    Mass (Da):28,600
    Last modified:November 8, 2005 - v1
    Checksum:i319CA48CCB310123
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028896 Genomic DNA. Translation: BAA82276.1.
    CP000114 Genomic DNA. Translation: ABA46124.1.
    RefSeqiWP_000565383.1. NC_007432.1.
    YP_007968738.1. NC_021195.1.
    YP_329875.1. NC_007432.1.

    Genome annotation databases

    EnsemblBacteriaiABA46124; ABA46124; SAK_1261.
    GeneIDi15485505.
    3686665.
    KEGGisagl:GBS222_1004.
    sak:SAK_1261.
    PATRICi19633797. VBIStrAga82541_1205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028896 Genomic DNA. Translation: BAA82276.1 .
    CP000114 Genomic DNA. Translation: ABA46124.1 .
    RefSeqi WP_000565383.1. NC_007432.1.
    YP_007968738.1. NC_021195.1.
    YP_329875.1. NC_007432.1.

    3D structure databases

    ProteinModelPortali Q3K0S8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205921.SAK_1261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA46124 ; ABA46124 ; SAK_1261 .
    GeneIDi 15485505.
    3686665.
    KEGGi sagl:GBS222_1004.
    sak:SAK_1261.
    PATRICi 19633797. VBIStrAga82541_1205.

    Phylogenomic databases

    eggNOGi COG4464.
    HOGENOMi HOG000007624.
    KOi K01104.
    OMAi TPHTLNG.
    OrthoDBi EOG6PKFDD.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .
    BioCyci SAGA205921:GHD7-1262-MONOMER.

    Family and domain databases

    InterProi IPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view ]
    Pfami PF02811. PHP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016557. Caps_synth_CpsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of type-specific capsular polysaccharide biosynthesis genes of Streptococcus agalactiae type Ia."
      Yamamoto S., Miyake K., Koike Y., Watanabe M., Machida Y., Ohta M., Iijima S.
      J. Bacteriol. 181:5176-5184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: OI1 / Serotype Ia.
    2. "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'."
      Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P.
      , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M.
      Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27591 / A909 / CDC SS700.

    Entry informationi

    Entry nameiCPSB_STRA1
    AccessioniPrimary (citable) accession number: Q3K0S8
    Secondary accession number(s): P0A365, Q9S0S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3