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Q3JZK5 (ALR_STRA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:SAK_1696
OrganismStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) [Complete proteome] [HAMAP]
Taxonomic identifier205921 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Alanine racemase HAMAP-Rule MF_01201
PRO_1000066041

Sites

Active site401Proton acceptor; specific for D-alanine By similarity
Active site2631Proton acceptor; specific for L-alanine By similarity
Binding site1361Substrate By similarity
Binding site3101Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3JZK5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: A2CDC66976DDA133

FASTA36640,064
        10         20         30         40         50         60 
MISSYHRPTR ALIDLEAIAN NVKSVQEHIP SDKKTFAVVK ANAYGHGAVE VSKYIESIVD 

        70         80         90        100        110        120 
GFCVSNLDEA IELRQAGIVK MILVLGVVMP EQVILAKNEN ITLTVASLEW LRLCQTSAVD 

       130        140        150        160        170        180 
LSGLEVHIKV DSGMGRIGVR QLDEGNKLIS ELGESGASVK GIFTHFATAD EADNCKFNQQ 

       190        200        210        220        230        240 
LTFFKDFISG LDNCPDLVHA SNSATSLWHS ETIFNAVRLG VVMYGLNPSG TDLDLPYPIN 

       250        260        270        280        290        300 
PALSLESELV HVKQLHDGSQ VGYGATYQVT GDEFVGTVPI GYADGWTRDM QGFSVIVNGE 

       310        320        330        340        350        360 
LCEIIGRVSM DQMTIRLPQK YTIGTKVTLI GQQGSCNITT TDVAQKRQTI NYEVLCLLSD 


RIPRYY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000114 Genomic DNA. Translation: ABA45793.1.
RefSeqYP_330298.1. NC_007432.1.

3D structure databases

ProteinModelPortalQ3JZK5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205921.SAK_1696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA45793; ABA45793; SAK_1696.
GeneID3687173.
KEGGsak:SAK_1696.
PATRIC19634708. VBIStrAga82541_1658.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAMAHFADA.
OrthoDBEOG6PP9NJ.
ProtClustDBPRK00053.

Enzyme and pathway databases

BioCycSAGA205921:GHD7-1697-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_STRA1
AccessionPrimary (citable) accession number: Q3JZK5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways