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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei263Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei310Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:SAK_1696
OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Taxonomic identifieri205921 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000660411 – 366Alanine racemaseAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ3JZK5

Structurei

3D structure databases

ProteinModelPortaliQ3JZK5
SMRiQ3JZK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3JZK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSYHRPTR ALIDLEAIAN NVKSVQEHIP SDKKTFAVVK ANAYGHGAVE
60 70 80 90 100
VSKYIESIVD GFCVSNLDEA IELRQAGIVK MILVLGVVMP EQVILAKNEN
110 120 130 140 150
ITLTVASLEW LRLCQTSAVD LSGLEVHIKV DSGMGRIGVR QLDEGNKLIS
160 170 180 190 200
ELGESGASVK GIFTHFATAD EADNCKFNQQ LTFFKDFISG LDNCPDLVHA
210 220 230 240 250
SNSATSLWHS ETIFNAVRLG VVMYGLNPSG TDLDLPYPIN PALSLESELV
260 270 280 290 300
HVKQLHDGSQ VGYGATYQVT GDEFVGTVPI GYADGWTRDM QGFSVIVNGE
310 320 330 340 350
LCEIIGRVSM DQMTIRLPQK YTIGTKVTLI GQQGSCNITT TDVAQKRQTI
360
NYEVLCLLSD RIPRYY
Length:366
Mass (Da):40,064
Last modified:November 8, 2005 - v1
Checksum:iA2CDC66976DDA133
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000114 Genomic DNA Translation: ABA45793.1
RefSeqiWP_000625941.1, NC_007432.1

Genome annotation databases

EnsemblBacteriaiABA45793; ABA45793; SAK_1696
KEGGisak:SAK_1696

Similar proteinsi

Entry informationi

Entry nameiALR_STRA1
AccessioniPrimary (citable) accession number: Q3JZK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health