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Q3JYQ4

- DEOC_STRA1

UniProt

Q3JYQ4 - DEOC_STRA1

Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

    Catalytic activityi

    2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei153 – 1531Schiff-base intermediate with acetaldehydeUniRule annotation
    Active sitei182 – 1821UniRule annotation

    GO - Molecular functioni

    1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate catabolic process Source: UniProtKB-HAMAP
    2. deoxyribonucleotide catabolic process Source: InterPro
    3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciSAGA205921:GHD7-2010-MONOMER.
    UniPathwayiUPA00002; UER00468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
    Short name:
    DERAUniRule annotation
    Alternative name(s):
    2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
    PhosphodeoxyriboaldolaseUniRule annotation
    Short name:
    DeoxyriboaldolaseUniRule annotation
    Gene namesi
    Name:deoCUniRule annotation
    Ordered Locus Names:SAK_2009
    OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    Taxonomic identifieri205921 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002701: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Deoxyribose-phosphate aldolasePRO_0000231567Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205921.SAK_2009.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3JYQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0274.
    HOGENOMiHOG000241645.
    KOiK01619.
    OMAiCEIAVEV.
    OrthoDBiEOG6QZMW5.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00114. DeoC_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view]
    PANTHERiPTHR10889. PTHR10889. 1 hit.
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001357. DeoC. 1 hit.
    TIGRFAMsiTIGR00126. deoC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3JYQ4-1 [UniParc]FASTAAdd to Basket

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    MEVKDILKTV DHTLLATTAT WPEIQTILDD AMAYETASAC IPASYVKKAA    50
    EYVSGKLAIC TVIGFPNGYS TTAAKVFECQ DAIKNGADEI DMVINLTDVK 100
    NGDFDTVEEE IRQIKAACQD HILKVIVETC QLTKEELIEL CGVVTRSGAD 150
    FIKTSTGFST AGATFEDVEV MAKYVGEGVK IKAAGGISSL EDAEKFIALG 200
    ASRLGTSRII KIVKNQKVEE GTY 223
    Length:223
    Mass (Da):24,017
    Last modified:November 8, 2005 - v1
    Checksum:i1629FF6D96E11EEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000114 Genomic DNA. Translation: ABA44945.1.
    RefSeqiYP_330599.1. NC_007432.1.

    Genome annotation databases

    EnsemblBacteriaiABA44945; ABA44945; SAK_2009.
    GeneIDi3685469.
    KEGGisak:SAK_2009.
    PATRICi19635370. VBIStrAga82541_1987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000114 Genomic DNA. Translation: ABA44945.1 .
    RefSeqi YP_330599.1. NC_007432.1.

    3D structure databases

    ProteinModelPortali Q3JYQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205921.SAK_2009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA44945 ; ABA44945 ; SAK_2009 .
    GeneIDi 3685469.
    KEGGi sak:SAK_2009.
    PATRICi 19635370. VBIStrAga82541_1987.

    Phylogenomic databases

    eggNOGi COG0274.
    HOGENOMi HOG000241645.
    KOi K01619.
    OMAi CEIAVEV.
    OrthoDBi EOG6QZMW5.

    Enzyme and pathway databases

    UniPathwayi UPA00002 ; UER00468 .
    BioCyci SAGA205921:GHD7-2010-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00114. DeoC_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view ]
    PANTHERi PTHR10889. PTHR10889. 1 hit.
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001357. DeoC. 1 hit.
    TIGRFAMsi TIGR00126. deoC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'."
      Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P.
      , Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., Fraser C.M.
      Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27591 / A909 / CDC SS700.

    Entry informationi

    Entry nameiDEOC_STRA1
    AccessioniPrimary (citable) accession number: Q3JYQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3