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Protein

Kynurenine formamidase

Gene

kynB

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-1055-MONOMER.
UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:BURPS1710b_1055
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002700 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Kynurenine formamidasePRO_0000362111Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ3JVD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219455.
KOiK07130.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3JVD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARVTLSPHTG
60 70 80 90 100
AHADAPLHYD ADGTPIGAVP LDAYLGRCRV IHCIGARSAV TPEHVRAALA
110 120 130 140 150
GAPPRVLLRT YGQAPQHAWN SAFCAVAPET IDLLAAHGVR LVGIDTPSLD
160 170 180 190 200
PQESKTMDAH RRIRAHRMAI LEGLVLDEIA AGDYELIALP LKFTTLDASP
210
VRAVLRALPD APR
Length:213
Mass (Da):22,755
Last modified:February 10, 2009 - v2
Checksum:i4F27B5EDCD24C0C3
GO

Sequence cautioni

The sequence ABA49041 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49041.1. Different initiation.
RefSeqiWP_038724085.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA49041; ABA49041; BURPS1710b_1055.
KEGGibpm:BURPS1710b_1055.
PATRICi19234354. VBIBurPse115837_1066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49041.1. Different initiation.
RefSeqiWP_038724085.1. NC_007434.1.

3D structure databases

ProteinModelPortaliQ3JVD6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA49041; ABA49041; BURPS1710b_1055.
KEGGibpm:BURPS1710b_1055.
PATRICi19234354. VBIBurPse115837_1066.

Phylogenomic databases

HOGENOMiHOG000219455.
KOiK07130.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.
BioCyciBPSE320372:GBYB-1055-MONOMER.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKYNB_BURP1
AccessioniPrimary (citable) accession number: Q3JVD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.