Q3JUM4 (UBIC2_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase 2
Short name=CL 2
Short name=CPL 2
EC=4.1.3.40

Gene names

Name:	ubiC2
Ordered Locus Names:	BURPS1710b_1319

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.
Sequence caution	The sequence ABA47638.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Probable chorismate--pyruvate lyase 2 HAMAP MF_01632		PRO_0000240540
Sites
	Binding site	73	1	Substrate By similarity
	Binding site	111	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JUM4 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: E009ED2A861D9EA1	FASTA	197	21,770
	10 20 30 40 50 60 MRFDAADAHW RETPRPGASS AQKDWLTRGG SLTAHLARLG RVTVRVTRET VAAPWADEHR 70 80 90 100 110 120 ALSCASRAPV WVREVVLAVD GAPFVAAHSI APLAASKGVW QAMRRLRTRP LAELLYSDPE 130 140 150 160 170 180 VTRSALVSRR VLAGHPLFSL ASLALARAYA TEHAFAARRS VFERRGTPLM VTECMLPALW 190 RHLDAHGERR ARGLEQT

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA47638.1. Different initiation.
RefSeq	YP_332729.1. NC_007434.1.
3D structure databases
ProteinModelPortal	Q3JUM4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JUM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3691106.
GenomeReviews	Gene locus BURPS1710b_1319 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_1319.
PATRIC	19234910. VBIBurPse115837_1342.
TIGR	BURPS1710b_1319.
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
ProtClustDB	CLSK920196.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC2_BURP1

Accession

Primary (citable) accession number: Q3JUM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program