Q3JTI8 (UPPP1_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Ordered Locus Names:	BURPS1710b_1713

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia pseudomallei

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006		PRO_0000227608
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	150 – 170	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3JTI8 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 27C258F7FAC6845D	FASTA	276	30,247
	10 20 30 40 50 60 MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV ALHLGTALAL 70 80 90 100 110 120 LWYFRERWIA LIAGFFASLN GRKNDEGHLM WALIIGTIPT GLVGLLLEKR IERVFHDLRI 130 140 150 160 170 180 VAAALIINGV LLWLGDRIQR ARAHRPPEKL TFKQAFFVGL AQVGALIPGF SRSGLTMIAG 190 200 210 220 230 240 NAAGLTADKA AEFSFLLGTP IIFAAGLLEL PKLFHAPDQL ADALLGGVLT AIAAYLSVRF 250 260 270 LMRYFEGRGR LASFGLYCVL AGLFCLGWFM FHAQPV

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA47658.1.
RefSeq	YP_333115.1. NC_007434.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	320372.BURPS1710b_1713.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA47658; ABA47658; BURPS1710b_1713.
GeneID	3689687.
KEGG	bpm:BURPS1710b_1713.
PATRIC	19235798. VBIBurPse115837_1779.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HMMWALI.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BPSE320372:GBYB-1713-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BURP1

Accession

Primary (citable) accession number: Q3JTI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 8, 2005
Last modified:	May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program