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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55ZincPROSITE-ProRule annotation1
Metal bindingi58ZincPROSITE-ProRule annotation1
Metal bindingi104ZincPROSITE-ProRule annotation1
Metal bindingi107ZincPROSITE-ProRule annotation1
Active sitei128NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:BURPS1710b_2458
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002700 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386171 – 143Peptide methionine sulfoxide reductase MsrBAdd BLAST143

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 22Combined sources7
Helixi25 – 33Combined sources9
Turni43 – 46Combined sources4
Beta strandi50 – 55Combined sources6
Turni56 – 58Combined sources3
Beta strandi61 – 64Combined sources4
Helixi65 – 67Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi77 – 80Combined sources4
Beta strandi86 – 92Combined sources7
Helixi94 – 96Combined sources3
Beta strandi99 – 104Combined sources6
Turni105 – 107Combined sources3
Beta strandi110 – 116Combined sources7
Turni120 – 123Combined sources4
Beta strandi126 – 129Combined sources4
Helixi131 – 133Combined sources3
Beta strandi134 – 138Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEZX-ray2.10A/B1-143[»]
3CXKX-ray1.70A/B1-143[»]
ProteinModelPortaliQ3JRF0.
SMRiQ3JRF0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3JRF0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 139MsrBPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRIEVQCK.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JRF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDRDDPRY PYPKDDAELR RRLTPMQYEV TQHAATEPPF TGEYTDTEDA
60 70 80 90 100
GIYHCVVCGT ALFESGAKYH SGCGWPSYFK PIDGEVIDEK MDYTHGMTRV
110 120 130 140
EVRCNQCGAH LGHVFEDGPR DKTGLRYCIN SAALNFEAKP ERK
Length:143
Mass (Da):16,187
Last modified:November 8, 2005 - v1
Checksum:iF964A5CC23725C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49928.1.
RefSeqiWP_004527204.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA49928; ABA49928; BURPS1710b_2458.
KEGGibpm:BURPS1710b_2458.
PATRICi19237392. VBIBurPse115837_2569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49928.1.
RefSeqiWP_004527204.1. NC_007434.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEZX-ray2.10A/B1-143[»]
3CXKX-ray1.70A/B1-143[»]
ProteinModelPortaliQ3JRF0.
SMRiQ3JRF0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA49928; ABA49928; BURPS1710b_2458.
KEGGibpm:BURPS1710b_2458.
PATRICi19237392. VBIBurPse115837_2569.

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRIEVQCK.

Miscellaneous databases

EvolutionaryTraceiQ3JRF0.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB_BURP1
AccessioniPrimary (citable) accession number: Q3JRF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.