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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551ZincPROSITE-ProRule annotation
Metal bindingi58 – 581ZincPROSITE-ProRule annotation
Metal bindingi104 – 1041ZincPROSITE-ProRule annotation
Metal bindingi107 – 1071ZincPROSITE-ProRule annotation
Active sitei128 – 1281NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-2458-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:BURPS1710b_2458
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002700 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Peptide methionine sulfoxide reductase MsrBPRO_0000338617Add
BLAST

Structurei

Secondary structure

1
143
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 227Combined sources
Helixi25 – 339Combined sources
Turni43 – 464Combined sources
Beta strandi50 – 556Combined sources
Turni56 – 583Combined sources
Beta strandi61 – 644Combined sources
Helixi65 – 673Combined sources
Beta strandi73 – 753Combined sources
Beta strandi77 – 804Combined sources
Beta strandi86 – 927Combined sources
Helixi94 – 963Combined sources
Beta strandi99 – 1046Combined sources
Turni105 – 1073Combined sources
Beta strandi110 – 1167Combined sources
Turni120 – 1234Combined sources
Beta strandi126 – 1294Combined sources
Helixi131 – 1333Combined sources
Beta strandi134 – 1385Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEZX-ray2.10A/B1-143[»]
3CXKX-ray1.70A/B1-143[»]
ProteinModelPortaliQ3JRF0.
SMRiQ3JRF0. Positions 10-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3JRF0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 139124MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JRF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDRDDPRY PYPKDDAELR RRLTPMQYEV TQHAATEPPF TGEYTDTEDA
60 70 80 90 100
GIYHCVVCGT ALFESGAKYH SGCGWPSYFK PIDGEVIDEK MDYTHGMTRV
110 120 130 140
EVRCNQCGAH LGHVFEDGPR DKTGLRYCIN SAALNFEAKP ERK
Length:143
Mass (Da):16,187
Last modified:November 8, 2005 - v1
Checksum:iF964A5CC23725C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49928.1.
RefSeqiWP_004527204.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA49928; ABA49928; BURPS1710b_2458.
KEGGibpm:BURPS1710b_2458.
PATRICi19237392. VBIBurPse115837_2569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49928.1.
RefSeqiWP_004527204.1. NC_007434.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEZX-ray2.10A/B1-143[»]
3CXKX-ray1.70A/B1-143[»]
ProteinModelPortaliQ3JRF0.
SMRiQ3JRF0. Positions 10-140.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA49928; ABA49928; BURPS1710b_2458.
KEGGibpm:BURPS1710b_2458.
PATRICi19237392. VBIBurPse115837_2569.

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-2458-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ3JRF0.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710b.
  2. "Methionine-R-sulfoxide reductase from Burkholderia pseudomallei."
    Seattle structural genomics center for infectious disease (SSGCID)
    Submitted (MAR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiMSRB_BURP1
AccessioniPrimary (citable) accession number: Q3JRF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 8, 2005
Last modified: April 13, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.