Reviewed, UniProtKB/Swiss-Prot Q3JR41 (LPXA_BURP1)

Names and origin

Protein names

Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
      Short name=UDP-N-acetylglucosamine acyltransferase
    EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	BURPS1710b_2570

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387		PRO_1000013156

Sequences

	Sequence		Length	Mass (Da)
	Q3JR41-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 70C4DC936E5933F6	FASTA	262	27,941
	10 20 30 40 50 60 MSRIHPTAII EPGAQLHETV EVGPYAIVGS HVTIGARTTI GSHSVIEGHT TIGEDNRIGH 70 80 90 100 110 120 YASVGGRPQD MKYKDEPTRL VIGDRNTIRE FTTIHTGTVQ DTGVTTLGDD NWIMAYVHIG 130 140 150 160 170 180 HDCRVGSHVI LSSNAQMAGH VEIGDWAIVG GMSGVHQFVR IGAHSMLGGA SALVQDIPPF 190 200 210 220 230 240 VIAAGNKAEP HGINVEGLRR RGFSPDAISA LRSAYRILYK NSLSLEEAKV QLSELAQAGG 250 260 DGDAAVKSLV DFVESSQRGI IR

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA50469.1.
RefSeq	YP_333962.1.
3D structure databases
SMR	Q3JR41. Positions 2-262.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JR41.
Genome annotation databases
GeneID	3689431.
GenomeReviews	Gene locus BURPS1710b_2570 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_2570.
TIGR	BURPS1710b_2570.
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HBG659295.
OMA	DLKYQGE.
Enzyme and pathway databases
BioCyc	BPSE320372:BURPS1710B_A2793-MONOMER.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
TIGRFAMs	TIGR01852. lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_BURP1

Accession

Primary (citable) accession number: Q3JR41

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)