Q3JQC8 (ASTE_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinylglutamate desuccinylase
EC=3.5.1.96

Gene names

Name:	astE
Ordered Locus Names:	BURPS1710b_2841

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transforms N(2)-succinylglutamate into succinate and glutamate. HAMAP MF_00767
Catalytic activity	N-succinyl-L-glutamate + H2O = succinate + L-glutamate. HAMAP MF_00767
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00767
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. HAMAP MF_00767
Sequence similarities	Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro succinylglutamate desuccinylase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Succinylglutamate desuccinylase HAMAP MF_00767		PRO_0000257707
Sites
	Active site	229	1	Potential
	Metal binding	70	1	Zinc By similarity
	Metal binding	73	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JQC8 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: FD0A3D0B70B5BFE9	FASTA	349	37,592
	10 20 30 40 50 60 MTSSADSGRD AAWLDDFLAL TLAGDAPPAE AGECAARAVR WRWLGDGLLR LEPADAAQRM 70 80 90 100 110 120 QSVLVSAGVH GDETAPIELL STLVRDIARG ALPLRCRLLV ALGNPGAMRA GERYLDDDLN 130 140 150 160 170 180 RLFGGRHAQL AASREAPRAA QLEAAAALFF STAGRARGAR WHIDMHTAIR ASVFEQFALL 190 200 210 220 230 240 PHTGEPPTRT MFEWLGEAQI AAVLLHTTKG STFSHFTAQA CGALACTLEL GKVMPFGAND 250 260 270 280 290 300 LSRFAPADAA VRRLVSGRRD APRGALPRAF TVVDQITKQS DALELFVAND VPNFTPFARG 310 320 330 340 TLLARDGDYR YAVRHEQERI VFPNPSVKPG LRAGLLVIET TRDTHAALA

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA48014.1.
RefSeq	YP_334225.1. NC_007434.1.
3D structure databases
HSSP	HSSP built from PDB template 2G9D based on UniProtKB Q9KSL4.
ProteinModelPortal	Q3JQC8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JQC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3691911.
GenomeReviews	Gene locus BURPS1710b_2841 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_2841.
PATRIC	19238224. VBIBurPse115837_2974.
TIGR	BURPS1710b_2841.
Phylogenomic databases
eggNOG	COG2988.
HOGENOM	HBG298271.
OMA	RWRWLGH.
ProtClustDB	PRK05324.
Enzyme and pathway databases
BioCyc	BPSE320372:BURPS1710B_A3086-MONOMER.
Family and domain databases
HAMAP	MF_00767. Arg_catab_AstE. [Tree]
InterPro	IPR007036. Aste_AspA. IPR016681. SuccinylGlu_desuccinylase. [Graphical view]
KO	K05526.
Pfam	PF04952. AstE_AspA. 1 hit. [Graphical view]
PIRSF	PIRSF017020. AstE. 1 hit.
TIGRFAMs	TIGR03242. Arg_catab_astE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASTE_BURP1

Accession

Primary (citable) accession number: Q3JQC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program