Q3JQA6 (PDXY_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxamine kinase
Short name=PM kinase
EC=2.7.1.35

Gene names

Name:	pdxY
Ordered Locus Names:	BURPS1710b_2863

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine By similarity. HAMAP MF_01639
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01639
Sequence similarities	Belongs to the pyridoxine kinase family.
Sequence caution	The sequence ABA49930.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxal 5'-phosphate salvage Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Pyridoxamine kinase HAMAP MF_01639		PRO_0000269799
Regions
	Nucleotide binding	180 – 181	2	ATP By similarity
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JQA6 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 1DAF47C6235AD2AE	FASTA	287	31,202
	10 20 30 40 50 60 MKNVLSIQSH VIYGHAGNSA AVFPMQRLGV NVWPLNTVQL SNHMQYGHWA GSAIDAAKME 70 80 90 100 110 120 QLVDGIAAIG ALKRCDAVLS GFLGSPAQAR AAVEIVRTVK ATNPNAWYFC DPAMGQTGGI 130 140 150 160 170 180 RPEPGVEEFI VAELPELADG MAPNHSELQK LAGQRIETVA EAVAACRLII RRGPQVILVK 190 200 210 220 230 240 HLHDRNSPAD RFNMLVVTET EAWIGQRPLY AFPRHPVGVG DLTSAIFVAR RLRGDSVRAA 250 260 270 280 FEHTLAAVHA VVKATYDARR YELELVAAQD EIARPSEWFG AWVTGAD

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA49930.1. Different initiation.
RefSeq	YP_334247.1. NC_007434.1.
3D structure databases
HSSP	HSSP built from PDB template 1YGJ based on UniProtKB P82197.
ProteinModelPortal	Q3JQA6.
SMR	Q3JQA6. Positions 1-281.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JQA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3690707.
GenomeReviews	Gene locus BURPS1710b_2863 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_2863.
PATRIC	19238262. VBIBurPse115837_2993.
TIGR	BURPS1710b_2863.
Phylogenomic databases
eggNOG	COG2240.
HOGENOM	HBG661459.
ProtClustDB	CLSK930954.
Family and domain databases
HAMAP	MF_01639. PdxY. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. IPR023685. Pyridoxal_kinase_PdxY. [Graphical view]
KO	K00868.
PANTHER	PTHR10534. PTHR10534. 1 hit.
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. Pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXY_BURP1

Accession

Primary (citable) accession number: Q3JQA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program