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Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 28ATPSequence analysis6
DNA bindingi377 – 396H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:BURPS1710b_3090
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002700 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002687981 – 641Bifunctional protein glkAdd BLAST641

Structurei

3D structure databases

ProteinModelPortaliQ3JPP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini341 – 417HTH rpiR-typeAdd BLAST77
Domaini461 – 600SISAdd BLAST140

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 340GlucokinaseAdd BLAST340
Regioni341 – 641Putative HTH-type transcriptional regulatorAdd BLAST301

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi591 – 639Ala-richAdd BLAST49

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.Curated
Contains 1 SIS domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000257466.
KOiK00845.
OMAiVSHSQVH.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JPP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGAQTKAA AASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA
60 70 80 90 100
EYPTLTDAIR KYLKDAKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA
110 120 130 140 150
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGGGTRR QNSVIGLMGP
160 170 180 190 200
GTGLGVSGLI PADDRWIALG SEGGHATFAP MDEREDLVLQ YARRKYPHVS
210 220 230 240 250
FERVCAGPGM EIIYRALAAR DKKRIAANVD TADIVERAHA GDALALEAVE
260 270 280 290 300
CFCAILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG
310 320 330 340 350
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM
360 370 380 390 400
RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC
410 420 430 440 450
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR
460 470 480 490 500
EHLNFEHVEQ AIDILNNARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY
510 520 530 540 550
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS
560 570 580 590 600
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAA
610 620 630 640
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK D
Length:641
Mass (Da):68,377
Last modified:November 8, 2005 - v1
Checksum:i3FD23867FE0AD167
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49272.1.
RefSeqiWP_004266877.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA49272; ABA49272; BURPS1710b_3090.
KEGGibpm:BURPS1710b_3090.
PATRICi19238732. VBIBurPse115837_3218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA49272.1.
RefSeqiWP_004266877.1. NC_007434.1.

3D structure databases

ProteinModelPortaliQ3JPP0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA49272; ABA49272; BURPS1710b_3090.
KEGGibpm:BURPS1710b_3090.
PATRICi19238732. VBIBurPse115837_3218.

Phylogenomic databases

HOGENOMiHOG000257466.
KOiK00845.
OMAiVSHSQVH.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLK_BURP1
AccessioniPrimary (citable) accession number: Q3JPP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.