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Q3JPP0

- GLK_BURP1

UniProt

Q3JPP0 - GLK_BURP1

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Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 286ATPSequence Analysis
DNA bindingi377 – 39620H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbohydrate binding Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. glucokinase activity Source: UniProtKB-EC
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-3090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:BURPS1710b_3090
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002700: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Bifunctional protein glkPRO_0000268798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320372.BURPS1710b_3090.

Structurei

3D structure databases

ProteinModelPortaliQ3JPP0.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 41777HTH rpiR-typeAdd
BLAST
Domaini461 – 600140SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 340340GlucokinaseAdd
BLAST
Regioni341 – 641301Putative HTH-type transcriptional regulatorAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi591 – 63949Ala-richAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.Curated
Contains 1 SIS domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JPP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTGAQTKAA AASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA
60 70 80 90 100
EYPTLTDAIR KYLKDAKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA
110 120 130 140 150
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGGGTRR QNSVIGLMGP
160 170 180 190 200
GTGLGVSGLI PADDRWIALG SEGGHATFAP MDEREDLVLQ YARRKYPHVS
210 220 230 240 250
FERVCAGPGM EIIYRALAAR DKKRIAANVD TADIVERAHA GDALALEAVE
260 270 280 290 300
CFCAILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG
310 320 330 340 350
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM
360 370 380 390 400
RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC
410 420 430 440 450
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR
460 470 480 490 500
EHLNFEHVEQ AIDILNNARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY
510 520 530 540 550
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS
560 570 580 590 600
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAA
610 620 630 640
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK D
Length:641
Mass (Da):68,377
Last modified:November 8, 2005 - v1
Checksum:i3FD23867FE0AD167
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000124 Genomic DNA. Translation: ABA49272.1.
RefSeqiYP_334463.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA49272; ABA49272; BURPS1710b_3090.
GeneIDi3691142.
KEGGibpm:BURPS1710b_3090.
PATRICi19238732. VBIBurPse115837_3218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000124 Genomic DNA. Translation: ABA49272.1 .
RefSeqi YP_334463.1. NC_007434.1.

3D structure databases

ProteinModelPortali Q3JPP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320372.BURPS1710b_3090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA49272 ; ABA49272 ; BURPS1710b_3090 .
GeneIDi 3691142.
KEGGi bpm:BURPS1710b_3090.
PATRICi 19238732. VBIBurPse115837_3218.

Phylogenomic databases

eggNOGi COG1737.
HOGENOMi HOG000257466.
KOi K00845.
OMAi QYARKKW.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci BPSE320372:GBYB-3090-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
TIGRFAMsi TIGR00749. glk. 1 hit.
PROSITEi PS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710b.

Entry informationi

Entry nameiGLK_BURP1
AccessioniPrimary (citable) accession number: Q3JPP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3