Q3JP41 (GMHA_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoheptose isomerase
EC=5.3.1.28

Alternative name(s):
Sedoheptulose 7-phosphate isomerase

Gene names

Name:	gmhA
Ordered Locus Names:	BURPS1710b_3291

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Catalytic activity	D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067
Pathway	Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067
Subunit structure	Homotetramer By similarity. HAMAP MF_00067
Subcellular location	Cytoplasm By similarity HAMAP MF_00067.
Miscellaneous	The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Sequence similarities	Belongs to the SIS family. GmhA subfamily. Contains 1 SIS domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-sedoheptulose 7-phosphate isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Phosphoheptose isomerase HAMAP MF_00067		PRO_1000009055
Regions
	Domain	40 – 197	158	SIS
	Region	55 – 57	3	Substrate binding By similarity
	Region	97 – 98	2	Substrate binding By similarity
	Region	123 – 125	3	Substrate binding By similarity
Sites
	Metal binding	64	1	Zinc By similarity
	Metal binding	68	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity
	Metal binding	183	1	Zinc By similarity
	Binding site	68	1	Substrate By similarity
	Binding site	128	1	Substrate By similarity
	Binding site	175	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JP41 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 63A1B00CA5E440D4	FASTA	197	20,784
	10 20 30 40 50 60 MENRELTYIT NSIAEAQRVM AAMLADERLL ATVQKVADAC IASIAQGGKV LLAGNGGSAA 70 80 90 100 110 120 DAQHIAGEFV SRFAFDRPGL PAVALTTDTS ILTAIGNDYG YEKLFSRQVQ ALGNKGDVLI 130 140 150 160 170 180 GYSTSGKSPN ILAAFREAKA KGMTCVGFTG NRGGEMRELC DLLLEVPSAD TPKIQEGHLV 190 LGHIVCGLVE HSIFGKQ

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA47697.1.
RefSeq	YP_334662.1. NC_007434.1.
3D structure databases
ProteinModelPortal	Q3JP41.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JP41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3690094.
GenomeReviews	Gene locus BURPS1710b_3291 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_3291.
PATRIC	19239154. VBIBurPse115837_3427.
TIGR	BURPS1710b_3291.
Phylogenomic databases
eggNOG	COG0279.
HOGENOM	HBG671955.
OMA	ECHICIG.
ProtClustDB	PRK13937.
Family and domain databases
HAMAP	MF_00067. GmhA. [Tree]
InterPro	IPR020620. Phosphoheptose_isomerase. IPR001347. SIS. [Graphical view]
KO	K03271.
Pfam	PF01380. SIS. 1 hit. [Graphical view]
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMHA_BURP1

Accession

Primary (citable) accession number: Q3JP41

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program