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Q3JP21

- PUR5_BURP1

UniProt

Q3JP21 - PUR5_BURP1

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPSE320372:GBYB-3311-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BURPS1710b_3311
    OrganismiBurkholderia pseudomallei (strain 1710b)
    Taxonomic identifieri320372 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002700: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258341Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi320372.BURPS1710b_3311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3JP21.
    SMRiQ3JP21. Positions 13-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3JP21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPPKSAPDA QGLSYRDAGV DIDAGDALVD KIKPFAKKTL RDGVLGGIGG    50
    FGALFEVPKK YREPVLVSGT DGVGTKLKLA FHLNKHDTVG QDLVAMSVND 100
    ILVQGAEPLF FLDYFACGKL DVETAATVVK GIATGCELAG CALIGGETAE 150
    MPGMYPDGEY DLAGFAVGAV EKSKIIDGST IAEGDVVLGL ASSGIHSNGF 200
    SLVRKIIERA NPDLSADFHG RSLADALMAP TRIYVKPLLA LMEKIAVKGM 250
    AHITGGGLVE NIPRVLRDGL TAELDQHAWP LPPLFQWLRQ HGGVADAEMH 300
    RVFNCGIGMA VIVSAADADD ALRQLADAGE QVWKIGTVRA SREGEAQTVV 350
    V 351
    Length:351
    Mass (Da):36,941
    Last modified:November 8, 2005 - v1
    Checksum:iBB27286317BCFCF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000124 Genomic DNA. Translation: ABA49845.1.
    RefSeqiYP_334682.1. NC_007434.1.

    Genome annotation databases

    EnsemblBacteriaiABA49845; ABA49845; BURPS1710b_3311.
    GeneIDi3689806.
    KEGGibpm:BURPS1710b_3311.
    PATRICi19239198. VBIBurPse115837_3449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000124 Genomic DNA. Translation: ABA49845.1 .
    RefSeqi YP_334682.1. NC_007434.1.

    3D structure databases

    ProteinModelPortali Q3JP21.
    SMRi Q3JP21. Positions 13-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320372.BURPS1710b_3311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA49845 ; ABA49845 ; BURPS1710b_3311 .
    GeneIDi 3689806.
    KEGGi bpm:BURPS1710b_3311.
    PATRICi 19239198. VBIBurPse115837_3449.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BPSE320372:GBYB-3311-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Woods D.E., Nierman W.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1710b.

    Entry informationi

    Entry nameiPUR5_BURP1
    AccessioniPrimary (citable) accession number: Q3JP21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3