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Q3JP06 (HEMH_BURP1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:BURPS1710b_3326
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Ferrochelatase HAMAP MF_00323
PRO_1000019283

Sites

Metal binding2261Iron By similarity
Metal binding3071Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3JP06 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: CB37193FB9181959

FASTA36740,571
        10         20         30         40         50         60 
MSFDSVPRHA LSMRFDLEPP SHASAAHRVA VLLVNLGTPD APTPRAVRRY LAQFLSDPRV 

        70         80         90        100        110        120 
VEIPQLVWQV ILRTLILPLR GRASAKKYAA VWLPEGSPLR VYTERQVESV KPLFAANGYR 

       130        140        150        160        170        180 
VIVDYAMRYG TPSIADVLAQ LKRAGAERVL LLPMYPQYSS STTATAFDAA FAALGRMRNQ 

       190        200        210        220        230        240 
PEVRTVRHYA DHPAYIHALA EQVRQYWAAH GRPAFDAGDK LVLSFHGVPK RTLDLGDPYH 

       250        260        270        280        290        300 
DQCQQTAALL MSALGLTTFE CRVTFQSRFG KAEWLQPYTA PTLKELGAAG VRRADVFCPG 

       310        320        330        340        350        360 
FTADCLETIE EIGIEVRDEF VHGGGKEFHR IPCLNASPAW IAALGEIAAE NLQGWPVRVA 


MAPEAVS

« Hide

References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000124 Genomic DNA. Translation: ABA51049.1.
RefSeqYP_334697.1. NC_007434.1.

3D structure databases

ProteinModelPortalQ3JP06.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3JP06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3691466.
GenomeReviewsGene locus BURPS1710b_3326 in contig CP000124_GR.
KEGGbpm:BURPS1710b_3326.
PATRIC19239230. VBIBurPse115837_3465.
TIGRBURPS1710b_3326.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBQ3JP06.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycBPSE320372:BURPS1710B_A3602-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_BURP1
AccessionPrimary (citable) accession number: Q3JP06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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