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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:BURPS1710b_3530
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002700 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002432681 – 203Dephospho-CoA kinaseAdd BLAST203

Structurei

3D structure databases

ProteinModelPortaliQ3JNF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 201DPCKUniRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020769.
KOiK00859.
OMAiKKRYPVS.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JNF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSVGLTGGI GSGKTTVADL FGKLGATIVD TDLIAHRITA PQGLAMPLIA
60 70 80 90 100
REFGAEFVAA DGSLDRAKMR ALVFSDESAR KRLEAITHPL IREETEREAR
110 120 130 140 150
TAQGAYVVFV VPLLVESGTW KTRVDRVLVV DCDVETQIAR VTARNGFTRA
160 170 180 190 200
QVEAIVARQA SRDARLAAAD DVIANDNASV AELAAEVAAL HQRYLECAAA

ARN
Length:203
Mass (Da):21,719
Last modified:November 8, 2005 - v1
Checksum:iD0E6CF8FF02B9853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA47879.1.
RefSeqiWP_004194322.1. NC_007434.1.

Genome annotation databases

EnsemblBacteriaiABA47879; ABA47879; BURPS1710b_3530.
KEGGibpm:BURPS1710b_3530.
PATRICi19239646. VBIBurPse115837_3672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000124 Genomic DNA. Translation: ABA47879.1.
RefSeqiWP_004194322.1. NC_007434.1.

3D structure databases

ProteinModelPortaliQ3JNF3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA47879; ABA47879; BURPS1710b_3530.
KEGGibpm:BURPS1710b_3530.
PATRICi19239646. VBIBurPse115837_3672.

Phylogenomic databases

HOGENOMiHOG000020769.
KOiK00859.
OMAiKKRYPVS.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_BURP1
AccessioniPrimary (citable) accession number: Q3JNF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.