ID   HIS4_BURP1              Reviewed;         251 AA.
AC   Q3JN01;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=BURPS1710b_3688;
OS   Burkholderia pseudomallei (strain 1710b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320372;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Woods D.E., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000124; ABA48864.1; -; Genomic_DNA.
DR   RefSeq; YP_335052.1; -.
DR   GeneID; 3690072; -.
DR   GenomeReviews; CP000124_GR; BURPS1710b_3688.
DR   KEGG; bpm:BURPS1710b_3688; -.
DR   TIGR; BURPS1710b_3688; -.
DR   HOGENOM; Q3JN01; -.
DR   OMA; Q3JN01; VATRGWL.
DR   BioCyc; BPSE320372:BURPS1710B_A3986-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    251       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000229046.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    131    131       Proton donor (By similarity).
SQ   SEQUENCE   251 AA;  26588 MW;  D4699D04E831232F CRC64;
     MLLIPAIDLK DGQCVRLKQG DMDQATIFSE DPAAMARKWV DLGARRLHLV DLNGAFAGKP
     KNLEAIEAIL GEVGDEIPVQ LGGGIRSLET IEKYLDAGLS YVIIGTAAVK DPGFLQDACS
     AFAGNIIVGL DAKDGKVATD GWSKLTGHEV IDLARKFEDY GVESIVYTDI GRDGMLQGIN
     IEATVKLAQA VGIPVIASGG LSNIVDIEKL CEVEDEGIEG VICGRAIYSG DLDFAAAQKR
     ADELNGELDD A
//