Q3JMW0 (AROK_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate kinase
Short name=SK
EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	BURPS1710b_3729

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity. HAMAP MF_00109
Subcellular location	Cytoplasm Probable HAMAP MF_00109.
Sequence similarities	Belongs to the shikimate kinase family.
Sequence caution	The sequence ABA49770.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW shikimate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Shikimate kinase HAMAP MF_00109		PRO_0000237859
Regions
	Nucleotide binding	17 – 22	6	ATP By similarity
Sites
	Metal binding	21	1	Magnesium By similarity
	Binding site	39	1	Substrate By similarity
	Binding site	63	1	Substrate By similarity
	Binding site	85	1	Substrate; via amide nitrogen By similarity
	Binding site	123	1	ATP By similarity
	Binding site	142	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JMW0 [UniParc]. Last modified May 30, 2006. Version 2. Checksum: BC2A5A026049D9B7	FASTA	184	20,715
	10 20 30 40 50 60 MQARDPHVNV IFVGLMGAGK TTVGRAVARR LDRPFFDSDH EIEARTGARI PVIFELEGEA 70 80 90 100 110 120 GFRDREAQMI AELTQRENIV LATGGGAILR PENRKLLHER GLVVYLRANP HDLWLRTRKD 130 140 150 160 170 180 KNRPLLQTDD PKAKLEALYE ARDPLYRECA HFVIETGRPS VNGLVNMVLM QLEMAGIVAK PLQA

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000124 Genomic DNA. Translation: ABA49770.1. Different initiation.
RefSeq	YP_335093.2. NC_007434.1.
3D structure databases
ProteinModelPortal	Q3JMW0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JMW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3691445.
GenomeReviews	Gene locus BURPS1710b_3729 in contig CP000124_GR.
KEGG	bpm:BURPS1710b_3729.
PATRIC	19240066. VBIBurPse115837_3876.
TIGR	BURPS1710b_3729.
Phylogenomic databases
eggNOG	COG0703.
HOGENOM	HBG335815.
PhylomeDB	Q3JMW0.
ProtClustDB	PRK00131.
Family and domain databases
HAMAP	MF_00109. Shikimate_kinase. [Tree]
InterPro	IPR000623. Shikimate_kinase. IPR023000. Shikimate_kinase_CS. [Graphical view]
KO	K00891.
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BURP1

Accession

Primary (citable) accession number: Q3JMW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program