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Q3JMT3 (Q3JMT3_BURP1) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY HAMAP-Rule MF_01465 RuleBase RU000537
Gene names
Name:secY HAMAP-Rule MF_01465 EMBL ABA49510.1
Ordered Locus Names:BURPS1710b_3756
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP] EMBL ABA49510.1
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. HAMAP-Rule MF_01465 RuleBase RU000537

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Membrane; Multi-pass membrane protein By similarity RuleBase RU003484.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. HAMAP-Rule MF_01465 RuleBase RU004349

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane25 – 4521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane78 – 9821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane126 – 14621Helical; By similarity HAMAP-Rule MF_01465
Transmembrane152 – 17221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane185 – 20521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane215 – 23521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane272 – 29221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane319 – 33921Helical; By similarity HAMAP-Rule MF_01465
Transmembrane375 – 39521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane399 – 41921Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
Q3JMT3 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 56B84B5CC9EA8F99

FASTA44848,975
        10         20         30         40         50         60 
MANSPSLAKP GRSTAKFGDL RRRAMFLLLA LIVYRIGAHI PVPGIDPDQL AKLFQSQAGG 

        70         80         90        100        110        120 
ILGMFNMFSG GALSRFTIFA LGIMPYISAS IIMQLMAIVS PQLEALKKEG QAGQRKITQY 

       130        140        150        160        170        180 
TRYFTVVLAT FQAFGIAAAL ENQPGLVTDP GAVFRLTTVV TLVTGTMFLM WLGEQITERG 

       190        200        210        220        230        240 
LGNGISIIIF GGIAAGFPNA VGGLFELVRT GSMSIISAII IVVLIAAVTY LVVFIERGQR 

       250        260        270        280        290        300 
KILVNYAKRQ VGNKIYGGQS SHLPLKLNMS GVIPPIFASS IILFPATILS WFSSGERKGW 

       310        320        330        340        350        360 
MSDTLHNVAE ALKPGQPVYV LLYTLAIVFF CFFYTALVFN SRETADNLKK SGAFVPGIRP 

       370        380        390        400        410        420 
GDQTARYIDR ILTRLTLAGA IYIVFVCLLP EFLVLRWNVP FYFGGTSLLI IVVVTMDFMA 

       430        440 
QVQSYVMSQQ YESLLKKANF KGGNIPMR

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References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b EMBL ABA49510.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000124 Genomic DNA. Translation: ABA49510.1.
RefSeqYP_335120.1. NC_007434.1.

3D structure databases

ProteinModelPortalQ3JMT3.
ModBaseSearch...

Protein-protein interaction databases

STRING320372.BURPS1710b_3756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA49510; ABA49510; BURPS1710b_3756.
GeneID3689706.
KEGGbpm:BURPS1710b_3756.
PATRIC19240118. VBIBurPse115837_3902.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0201.
HOGENOMHOG000080585.
KOK03076.
OMAFIMWLGE.
ProtClustDBPRK09204.

Enzyme and pathway databases

BioCycBPSE320372:GBYB-3755-MONOMER.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ3JMT3_BURP1
AccessionPrimary (citable) accession number: Q3JMT3
Entry history
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 29, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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