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Q3JME7

- THIM_BURP1

UniProt

Q3JME7 - THIM_BURP1

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261ATPUniRule annotation
Binding sitei172 – 1721ATPUniRule annotation
Binding sitei199 – 1991Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-3895-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:BURPS1710b_A0097
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002700: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Hydroxyethylthiazole kinasePRO_0000383828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320372.BURPS1710b_A0097.

Structurei

3D structure databases

ProteinModelPortaliQ3JME7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OrthoDBiEOG6677TX.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3JME7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESISWNTPS VRDALAAVKR DAPFIYGLTN YVAANLSANV LLAVGAAPAI
60 70 80 90 100
GAAADWPARF GAGANALWIN TAALMSSGAD TLLTAARAAS KAGTRWVLDP
110 120 130 140 150
VALGAGAPEY DAIVRDLLAL RPTVIRGNAS ELIALAGGTA AGKGVDTTAS
160 170 180 190 200
PESALAFIGD LARRSGAVVS VSGPTDYVTD GVATLAVAGG DARLTRVTGA
210 220 230 240 250
GCALGALIAA LLAQRGAALA AASAAHAIYA TAAERAADAR GTASFAVRFV
260 270
DELSLLDPAE SSRDRSAGQI GAKRRE
Length:276
Mass (Da):27,540
Last modified:September 22, 2009 - v2
Checksum:i3384D9EDF6A8B60E
GO

Sequence cautioni

The sequence ABA53542.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000125 Genomic DNA. Translation: ABA53542.1. Different initiation.
RefSeqiYP_335256.1. NC_007435.1.

Genome annotation databases

EnsemblBacteriaiABA53542; ABA53542; BURPS1710b_A0097.
GeneIDi3692203.
KEGGibpm:BURPS1710b_A0097.
PATRICi19240427. VBIBurPse115837_4052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000125 Genomic DNA. Translation: ABA53542.1 . Different initiation.
RefSeqi YP_335256.1. NC_007435.1.

3D structure databases

ProteinModelPortali Q3JME7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320372.BURPS1710b_A0097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA53542 ; ABA53542 ; BURPS1710b_A0097 .
GeneIDi 3692203.
KEGGi bpm:BURPS1710b_A0097.
PATRICi 19240427. VBIBurPse115837_4052.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OrthoDBi EOG6677TX.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci BPSE320372:GBYB-3895-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710b.

Entry informationi

Entry nameiTHIM_BURP1
AccessioniPrimary (citable) accession number: Q3JME7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 1, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3