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Q3JLL8 (BETB_BURP1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:BURPS1710b_A0376
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000047038

Regions

Nucleotide binding228 – 2336NAD By similarity

Sites

Active site2511 By similarity
Active site2851 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3JLL8 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: B53067B29C8665F5

FASTA48952,191
        10         20         30         40         50         60 
MSVYGLQRLY IAGAHADATS GKTFDTFDPA TGELLARVQQ ASADDVDRAV ASAREGQREW 

        70         80         90        100        110        120 
AAMTAMQRSR ILRRAVELLR ERNDALAELE MRDTGKPIAE TRAVDIVTGA DVIEYYAGLA 

       130        140        150        160        170        180 
TAIEGLQVPL RPESFVYTRR EPLGVCAGIG AWNYPIQIAC WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLSALKLAE IYTEAGVPAG VFNVVQGDGS VGALLSAHPG IAKVSFTGGV ETGKKVMSLA 

       250        260        270        280        290        300 
GASSLKEVTM ELGGKSPLIV FDDADLDRAA DIAVTANFFS AGQVCTNGTR VFVQQAVKDA 

       310        320        330        340        350        360 
FVERVLARVA RIRVGKPSDS DTNFGPLASA AQLDKVLGYI DSGKAEGAKL LAGGARLVND 

       370        380        390        400        410        420 
HFASGQYVAP TVFGDCRDDM RIVREEIFGP VMSILSFETE DEAIARANAT DYGLAAGVVT 

       430        440        450        460        470        480 
ENLSRAHRAI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGITTLE HYTRIKSVQV 


ELGRYQPVF

« Hide

References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000125 Genomic DNA. Translation: ABA51910.1.
RefSeqYP_335535.1. NC_007435.1.

3D structure databases

HSSPHSSP built from PDB template 1BPW based on UniProtKB P56533.
ProteinModelPortalQ3JLL8.
SMRQ3JLL8. Positions 8-489.
ModBaseSearch...

Protein-protein interaction databases

STRING320372.BURPS1710b_A0376.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA51910; ABA51910; BURPS1710b_A0376.
GeneID3692091.
KEGGbpm:BURPS1710b_A0376.
PATRIC19241065. VBIBurPse115837_4371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAGTDTGKK.
ProtClustDBPRK13252.

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_BURP1
AccessionPrimary (citable) accession number: Q3JLL8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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