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Q3JLL7 (BETA_BURP1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:BURPS1710b_A0377
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Choline dehydrogenase HAMAP MF_00750
PRO_0000258920

Regions

Nucleotide binding7 – 3630FAD Potential

Sites

Active site4741 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3JLL7 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: B3C063535E7AB460

FASTA56562,689
        10         20         30         40         50         60 
MTTREFDYII CGAGSAGNVL ATRLTEDPGV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYETD PEPHMNHRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW ATHKGLEDWA 

       130        140        150        160        170        180 
YLDCLPYFRK AETRDVGPND YHGGDGPVSV TTSKPGVNPL FEAMVEAGVQ AGYPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTPRGRR ASTARGYLDQ ARARPNLEIV THALADRILF SGKRATGVTF 

       250        260        270        280        290        300 
LHGSARVTAH ARREVLVCSG AIASPQLLQR SGVGPGEWLR ELDIPVVLDL PGVGRNLQDH 

       310        320        330        340        350        360 
LEMYIQFECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN 

       370        380        390        400        410        420 
IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL KSRDPHAHPS ILFNYMAEAL 

       430        440        450        460        470        480 
DWREFRDAIR ATREIMRQPA LDRFRGRELN PGADLKSDNE LDTFVRARAE TAFHPSCSCK 

       490        500        510        520        530        540 
MGYDDMAVVD NEGRVHGIDG LRVVDASIMP IITTGNLNAP TIMIAEKIAD RIRKHKPLER 

       550        560 
SNAQYYVANG APARGGKPAR APAVV

« Hide

References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000125 Genomic DNA. Translation: ABA51751.1.
RefSeqYP_335536.1. NC_007435.1.

3D structure databases

ProteinModelPortalQ3JLL7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3JLL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3692830.
GenomeReviewsGene locus BURPS1710b_A0377 in contig CP000125_GR.
KEGGbpm:BURPS1710b_A0377.
PATRIC19241067. VBIBurPse115837_4372.
TIGRBURPS1710b_A0377.

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHBG734713.
OMARSTAPYY.
ProtClustDBPRK02106.

Enzyme and pathway databases

BioCycBPSE320372:BURPS1710B_B0453-MONOMER.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_BURP1
AccessionPrimary (citable) accession number: Q3JLL7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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