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Q3JL79 (NADE_BURP1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NH(3)-dependent NAD(+) synthetase
EC=6.3.1.5
Gene names
Name:nadE
Ordered Locus Names:BURPS1710b_A0515
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193

Sequence similarities

Belongs to the NAD synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
PRO_1000099011

Regions

Nucleotide binding51 – 588ATP By similarity

Sites

Active site531 By similarity

Secondary structure

1 ...................................... 284
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q3JL79 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 8AF21BEE0B0BCEAF

FASTA28430,882
        10         20         30         40         50         60 
MSRPDQAARR RAIAAELHVS PTFDARDEAE RRIGFVADYL RTAGLRACVL GISGGIDSST 

        70         80         90        100        110        120 
AGRLAQLAVE RLRASGYDAR FVAMRLPYGA QHDEADARRA LAFVRADETL TVDVKPAADA 

       130        140        150        160        170        180 
MLAALAAGGL AYLDHAQQDF VLGNIKARER MIAQYAVAGA RNGVVIGTDH AAESVMGFFT 

       190        200        210        220        230        240 
KFGDGGADVL PLAGLTKRRV RALARMLGAD EPLVLKTPTA DLETLRPQRP DEHAYGITYE 

       250        260        270        280 
QIDDFLEGKP MDDAVAETVL RFYDATRHKR ALPYTMFDWP GHPA

« Hide

References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000125 Genomic DNA. Translation: ABA53106.1.
RefSeqYP_335674.1. NC_007435.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DPIX-ray2.20A/B1-284[»]
ProteinModelPortalQ3JL79.
SMRQ3JL79. Positions 11-278.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3JL79.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3692058.
GenomeReviewsGene locus BURPS1710b_A0515 in contig CP000125_GR.
KEGGbpm:BURPS1710b_A0515.
PATRIC19241383. VBIBurPse115837_4530.
TIGRBURPS1710b_A0515.

Phylogenomic databases

eggNOGCOG0171.
HOGENOMHBG351567.
OMAIAQYEIA.
ProtClustDBPRK00768.

Enzyme and pathway databases

BioCycBPSE320372:BURPS1710B_B0616-MONOMER.

Family and domain databases

HAMAPMF_00193. NadE.
[Tree]
InterProIPR022310. NAD/GMP_synthase.
IPR003694. NAD_synthase.
IPR022926. NH(3)-dep_NAD(+)_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01916.
PfamPF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00552. NadE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADE_BURP1
AccessionPrimary (citable) accession number: Q3JL79
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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