Q3JKA4 (GCH4_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	BURPS1710b_A0841

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia pseudomallei

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000289480
Sites
	Site	151	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3JKA4 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: E044BFDEC51BF31F	FASTA	266	29,830
	10 20 30 40 50 60 MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN LDVHLPADQK 70 80 90 100 110 120 GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR IEVSFPYFVN KTAPVSGVRS 130 140 150 160 170 180 LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL CPCSKKISQY GAHNQRSHVT IDAELAADVP 190 200 210 220 230 240 VEDLIRIAEE EASCELWGLL KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV 250 260 LEAENFESIH NHSAYALIER DKRRGA

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000125 Genomic DNA. Translation: ABA52207.1.
RefSeq	YP_335999.1. NC_007435.1.
3D structure databases
ProteinModelPortal	Q3JKA4.
SMR	Q3JKA4. Positions 18-262.
ModBase	Search...
Protein-protein interaction databases
STRING	320372.BURPS1710b_A0841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA52207; ABA52207; BURPS1710b_A0841.
GeneID	3692036.
KEGG	bpm:BURPS1710b_A0841.
PATRIC	19242085. VBIBurPse115837_4880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	BPSE320372:GBYB-4639-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_BURP1

Accession

Primary (citable) accession number: Q3JKA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 8, 2005
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program