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Q3JKA4

- GCH4_BURP1

UniProt

Q3JKA4 - GCH4_BURP1

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-4639-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BURPS1710b_A0841
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002700: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2PRO_0000289480Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320372.BURPS1710b_A0841.

Structurei

3D structure databases

ProteinModelPortaliQ3JKA4.
SMRiQ3JKA4. Positions 18-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JKA4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN
60 70 80 90 100
LDVHLPADQK GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR
110 120 130 140 150
IEVSFPYFVN KTAPVSGVRS LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL
160 170 180 190 200
CPCSKKISQY GAHNQRSHVT IDAELAADVP VEDLIRIAEE EASCELWGLL
210 220 230 240 250
KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV LEAENFESIH
260
NHSAYALIER DKRRGA
Length:266
Mass (Da):29,830
Last modified:November 8, 2005 - v1
Checksum:iE044BFDEC51BF31F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000125 Genomic DNA. Translation: ABA52207.1.
RefSeqiYP_335999.1. NC_007435.1.

Genome annotation databases

EnsemblBacteriaiABA52207; ABA52207; BURPS1710b_A0841.
GeneIDi3692036.
KEGGibpm:BURPS1710b_A0841.
PATRICi19242085. VBIBurPse115837_4880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000125 Genomic DNA. Translation: ABA52207.1 .
RefSeqi YP_335999.1. NC_007435.1.

3D structure databases

ProteinModelPortali Q3JKA4.
SMRi Q3JKA4. Positions 18-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320372.BURPS1710b_A0841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA52207 ; ABA52207 ; BURPS1710b_A0841 .
GeneIDi 3692036.
KEGGi bpm:BURPS1710b_A0841.
PATRICi 19242085. VBIBurPse115837_4880.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BPSE320372:GBYB-4639-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710b.

Entry informationi

Entry nameiGCH4_BURP1
AccessioniPrimary (citable) accession number: Q3JKA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3