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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-4639-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BURPS1710b_A0841
OrganismiBurkholderia pseudomallei (strain 1710b)
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002700: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2PRO_0000289480Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320372.BURPS1710b_A0841.

Structurei

3D structure databases

ProteinModelPortaliQ3JKA4.
SMRiQ3JKA4. Positions 18-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JKA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN
60 70 80 90 100
LDVHLPADQK GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR
110 120 130 140 150
IEVSFPYFVN KTAPVSGVRS LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL
160 170 180 190 200
CPCSKKISQY GAHNQRSHVT IDAELAADVP VEDLIRIAEE EASCELWGLL
210 220 230 240 250
KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV LEAENFESIH
260
NHSAYALIER DKRRGA
Length:266
Mass (Da):29,830
Last modified:November 8, 2005 - v1
Checksum:iE044BFDEC51BF31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000125 Genomic DNA. Translation: ABA52207.1.
RefSeqiYP_335999.1. NC_007435.1.

Genome annotation databases

EnsemblBacteriaiABA52207; ABA52207; BURPS1710b_A0841.
GeneIDi3692036.
KEGGibpm:BURPS1710b_A0841.
PATRICi19242085. VBIBurPse115837_4880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000125 Genomic DNA. Translation: ABA52207.1.
RefSeqiYP_335999.1. NC_007435.1.

3D structure databases

ProteinModelPortaliQ3JKA4.
SMRiQ3JKA4. Positions 18-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi320372.BURPS1710b_A0841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA52207; ABA52207; BURPS1710b_A0841.
GeneIDi3692036.
KEGGibpm:BURPS1710b_A0841.
PATRICi19242085. VBIBurPse115837_4880.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciBPSE320372:GBYB-4639-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710b.

Entry informationi

Entry nameiGCH4_BURP1
AccessioniPrimary (citable) accession number: Q3JKA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.