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Q3JKA4 (GCH4_BURP1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BURPS1710b_A0841
OrganismBurkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]
Taxonomic identifier320372 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289480

Sites

Site1511May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3JKA4 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: E044BFDEC51BF31F

FASTA26629,830
        10         20         30         40         50         60 
MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN LDVHLPADQK 

        70         80         90        100        110        120 
GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR IEVSFPYFVN KTAPVSGVRS 

       130        140        150        160        170        180 
LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL CPCSKKISQY GAHNQRSHVT IDAELAADVP 

       190        200        210        220        230        240 
VEDLIRIAEE EASCELWGLL KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV 

       250        260 
LEAENFESIH NHSAYALIER DKRRGA 

« Hide

References

[1]Woods D.E., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1710b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000125 Genomic DNA. Translation: ABA52207.1.
RefSeqYP_335999.1. NC_007435.1.

3D structure databases

ProteinModelPortalQ3JKA4.
SMRQ3JKA4. Positions 18-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING320372.BURPS1710b_A0841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA52207; ABA52207; BURPS1710b_A0841.
GeneID3692036.
KEGGbpm:BURPS1710b_A0841.
PATRIC19242085. VBIBurPse115837_4880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycBPSE320372:GBYB-4639-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BURP1
AccessionPrimary (citable) accession number: Q3JKA4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways