Q3JK86 (KHSE_BURP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BURPS1710b_A0859

Organism

Burkholderia pseudomallei (strain 1710b) [Complete proteome] [HAMAP]

Taxonomic identifier

320372 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.
Sequence caution	The sequence ABA51556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Homoserine kinase HAMAP MF_00301		PRO_0000322239

Sequences

	Sequence		Length	Mass (Da)
	Q3JK86 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6D14A50910891BD5	FASTA	331	36,759
	10 20 30 40 50 60 MAVFTAVSNA DLALWMRHYD LGDVVAFRGI PSGIENSNFF LTTTRGEYVL TIFENLTAGQ 70 80 90 100 110 120 LPFYVDLMSH LAKHGVPVPA PVARDDGTLF GELHGKPAAI VTKLEGAAQL APGVEHCVEV 130 140 150 160 170 180 GQMLARMHLA GRDYPRHQPN LRSLPWWRDT VPAIAPFVTG EQRALLEGEL AHQAAFFASD 190 200 210 220 230 240 DYAALPEGPC HCDLFRDNAL FAHAEPDTGH SVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLPTGALDA ARADALLRAY QTVRPFTAGE RRHWGDMLRA GAYRFWVSRL YDFHLPRAAQ 310 320 330 MLKPHDPGHF ERILRERIAH AGALPETHAC N

References

[1]	Woods D.E., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1710b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000125 Genomic DNA. Translation: ABA51556.1. Different initiation.
RefSeq	YP_336017.1. NC_007435.1.
3D structure databases
ProteinModelPortal	Q3JK86.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JK86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3694063.
GenomeReviews	Gene locus BURPS1710b_A0859 in contig CP000125_GR.
KEGG	bpm:BURPS1710b_A0859.
PATRIC	19242133. VBIBurPse115837_4904.
TIGR	BURPS1710b_A0859.
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURP1

Accession

Primary (citable) accession number: Q3JK86

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program