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Q3JK54

- ACDH_BURP1

UniProt

Q3JK54 - ACDH_BURP1

Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
    Binding sitei272 – 2721NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi162 – 1709NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBPSE320372:GBYB-4689-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:BURPS1710b_A0891
    OrganismiBurkholderia pseudomallei (strain 1710b)
    Taxonomic identifieri320372 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002700: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Acetaldehyde dehydrogenasePRO_0000387636Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi320372.BURPS1710b_A0891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3JK54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHQGNVNM.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3JK54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSKSSRTRV AILGSGSIGL DLMFKVKASE QFDLKFVVGR NANSDGLRLA    50
    RSCNVETSSD GLDFLKAHED AYDLVFDATS AAAHKVNNRF FSDAGKFVID 100
    LTPAKVGRLC VPCINLDDMG AEQNVNLITC GGQASLPLAY ALKQAVDEID 150
    YLEVVSAIAS RSAGIATREN IDEYMTTTEY ALAKFSGAKK TKAILNINPA 200
    EPGVRMQTTL YAYARYRDFD RVRASVADMV EKVREYVPGY RLVVEPLESQ 250
    GRITIGLTVR GRGDYLPEYA GNLDIINCAA LAVASHRHAT ARLGATQ 297
    Length:297
    Mass (Da):32,288
    Last modified:November 8, 2005 - v1
    Checksum:i257A95CEF258323B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000125 Genomic DNA. Translation: ABA53130.1.
    RefSeqiYP_336049.1. NC_007435.1.

    Genome annotation databases

    EnsemblBacteriaiABA53130; ABA53130; BURPS1710b_A0891.
    GeneIDi3692453.
    KEGGibpm:BURPS1710b_A0891.
    PATRICi19242201. VBIBurPse115837_4938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000125 Genomic DNA. Translation: ABA53130.1 .
    RefSeqi YP_336049.1. NC_007435.1.

    3D structure databases

    ProteinModelPortali Q3JK54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320372.BURPS1710b_A0891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA53130 ; ABA53130 ; BURPS1710b_A0891 .
    GeneIDi 3692453.
    KEGGi bpm:BURPS1710b_A0891.
    PATRICi 19242201. VBIBurPse115837_4938.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HQGNVNM.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BPSE320372:GBYB-4689-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Woods D.E., Nierman W.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1710b.

    Entry informationi

    Entry nameiACDH_BURP1
    AccessioniPrimary (citable) accession number: Q3JK54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3