ID Q3JK38_BURP1 Unreviewed; 113 AA. AC Q3JK38; DT 08-NOV-2005, integrated into UniProtKB/TrEMBL. DT 08-NOV-2005, sequence version 1. DT 27-MAR-2024, entry version 132. DE RecName: Full=Peptidyl-prolyl cis-trans isomerase {ECO:0000256|RuleBase:RU003915}; DE EC=5.2.1.8 {ECO:0000256|RuleBase:RU003915}; GN OrderedLocusNames=BURPS1710b_A0907 {ECO:0000313|EMBL:ABA51599.1}; OS Burkholderia pseudomallei (strain 1710b). OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=320372 {ECO:0000313|EMBL:ABA51599.1, ECO:0000313|Proteomes:UP000002700}; RN [1] {ECO:0000313|EMBL:ABA51599.1, ECO:0000313|Proteomes:UP000002700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1710b {ECO:0000313|EMBL:ABA51599.1, RC ECO:0000313|Proteomes:UP000002700}; RA Zhang L., Ge S.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PDB:2L2S} RP STRUCTURE BY NMR. RA Norville I.H., O'Shea K., Sarkar-Tyson M., Zheng S., Titball R.W., RA Varani G., Harmer N.J.; RT "Solution structure of peptidyl-prolyl cis-trans isomerase from RT Burkholderia pseudomallei complexed with 1-{[(4- RT methylphenyl)thio]acetyl}piperidine."; RL Submitted (AUG-2010) to the PDB data bank. RN [3] {ECO:0007829|PDB:3UF8, ECO:0007829|PDB:3UQB} RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-113 IN COMPLEX WITH CALCIUM. RX PubMed=24366729; DOI=10.1128/AAC.01875-13; RA Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., RA Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., RA Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., RA Norville I.H., Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.; RT "A structural biology approach enables the development of antimicrobials RT targeting bacterial immunophilins."; RL Antimicrob. Agents Chemother. 58:1458-1467(2014). RN [4] {ECO:0007829|PDB:5KLX} RP X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 3-113. RA Lorimer D.D., Fox III D., Seufert F., Edwards T.E., Holzgrabe U.; RT "Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from RT Burkholderia Pseudomallei Complexed with SF110."; RL Submitted (JUN-2016) to the PDB data bank. RN [5] {ECO:0007829|PDB:6O49} RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 3-113 IN COMPLEX WITH CA(2+). RA Iwasaki J., Lorimer D.D., Vivoli M., Harmer N.J., Kibble E.A., RA Peacock C.S., Abendroth J., Mayclin S.J., Dranow D.M., Pierce P.G., RA Fox III D., Lewis M., Bzdyl N., Kristensen S., Schmidberger J.W., RA Bond C.B., Seufert F., Schmitz J., Norville I.H., Myler P.J., Holzgrabe U., RA Sarkar-Tyson M.; RT "CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM RT BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339."; RL Submitted (FEB-2019) to the PDB data bank. RN [6] {ECO:0007829|PDB:6O4A} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 3-113. RA Iwasaki J., Lorimer D.D., Vivoli M., Harmer N.J., Kibble E.A., RA Peacock C.S., Abendroth J., Mayclin S.J., Dranow D.M., Pierce P.G., RA Fox III D., Lewis M., Bzdyl N., Kristensen S., Schmidberger J.W., RA Bond C.B., Seufert F., Schmitz J., Norville I.H., Myler P.J., Holzgrabe U., RA Sarkar-Tyson M.; RT "CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM RT BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355."; RL Submitted (FEB-2019) to the PDB data bank. CC -!- CATALYTIC ACTIVITY: CC Reaction=[protein]-peptidylproline (omega=180) = [protein]- CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, CC ChEBI:CHEBI:83834; EC=5.2.1.8; CC Evidence={ECO:0000256|ARBA:ARBA00000971, ECO:0000256|PROSITE- CC ProRule:PRU00277, ECO:0000256|RuleBase:RU003915}; CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family. CC {ECO:0000256|ARBA:ARBA00006577, ECO:0000256|RuleBase:RU003915}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000125; ABA51599.1; -; Genomic_DNA. DR RefSeq; WP_004525093.1; NC_007435.1. DR PDB; 2L2S; NMR; -; A=1-113. DR PDB; 3UF8; X-ray; 1.50 A; A=2-113. DR PDB; 3UQB; X-ray; 1.90 A; A=3-113. DR PDB; 3VAW; X-ray; 1.55 A; A=2-113. DR PDB; 4DZ2; X-ray; 2.00 A; A/B=2-113. DR PDB; 4DZ3; X-ray; 2.00 A; A/B=2-113. DR PDB; 4FN2; X-ray; 1.95 A; A/B=2-113. DR PDB; 4G50; X-ray; 1.75 A; A/B=2-113. DR PDB; 4GGQ; X-ray; 1.95 A; A/B/C/D=3-113. DR PDB; 4GIV; X-ray; 2.45 A; A/B=2-113. DR PDB; 5KLX; X-ray; 2.45 A; A/B/C/D=2-113. DR PDB; 6O49; X-ray; 1.85 A; A/B=3-113. DR PDB; 6O4A; X-ray; 2.10 A; A/B/C/D=2-113. DR PDBsum; 2L2S; -. DR PDBsum; 3UF8; -. DR PDBsum; 3UQB; -. DR PDBsum; 3VAW; -. DR PDBsum; 4DZ2; -. DR PDBsum; 4DZ3; -. DR PDBsum; 4FN2; -. DR PDBsum; 4G50; -. DR PDBsum; 4GGQ; -. DR PDBsum; 4GIV; -. DR PDBsum; 5KLX; -. DR PDBsum; 6O49; -. DR PDBsum; 6O4A; -. DR AlphaFoldDB; Q3JK38; -. DR SMR; Q3JK38; -. DR EnsemblBacteria; ABA51599; ABA51599; BURPS1710b_A0907. DR KEGG; bpm:BURPS1710b_A0907; -. DR HOGENOM; CLU_013615_12_0_4; -. DR EvolutionaryTrace; Q3JK38; -. DR Proteomes; UP000002700; Chromosome II. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006457; P:protein folding; IEA:UniProt. DR Gene3D; 3.10.50.40; -; 1. DR InterPro; IPR046357; PPIase_dom_sf. DR InterPro; IPR001179; PPIase_FKBP_dom. DR PANTHER; PTHR43811:SF19; 39 KDA FK506-BINDING NUCLEAR PROTEIN; 1. DR PANTHER; PTHR43811; FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA; 1. DR Pfam; PF00254; FKBP_C; 1. DR SUPFAM; SSF54534; FKBP-like; 1. DR PROSITE; PS50059; FKBP_PPIASE; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2L2S, ECO:0007829|PDB:3UF8}; KW Calcium {ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3}; KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277, KW ECO:0000256|RuleBase:RU003915}; KW Metal-binding {ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3}; KW Rotamase {ECO:0000256|ARBA:ARBA00023110, ECO:0000256|PROSITE- KW ProRule:PRU00277}. FT DOMAIN 26..113 FT /note="PPIase FKBP-type" FT /evidence="ECO:0000259|PROSITE:PS50059" FT BINDING 51 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:4GGQ, ECO:0007829|PDB:6O49" FT BINDING 51 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3" FT BINDING 51 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0007829|PDB:5KLX" FT BINDING 52 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:4GGQ, ECO:0007829|PDB:6O49" FT BINDING 52 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3" FT BINDING 52 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0007829|PDB:5KLX" FT BINDING 112 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3" FT BINDING 113 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4DZ2, ECO:0007829|PDB:4DZ3" SQ SEQUENCE 113 AA; 11930 MW; 10AB26FB56F3F284 CRC64; MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP NATLVFEVEL LDV //