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Q3JK38

- Q3JK38_BURP1

UniProt

Q3JK38 - Q3JK38_BURP1

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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

BURPS1710b_A0907

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511CalciumImported
Metal bindingi52 – 521Calcium; via carbonyl oxygenImported
Metal bindingi112 – 1121CalciumImported
Metal bindingi113 – 1131Calcium; via amide nitrogen and carbonyl oxygenImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciBPSE320372:GBYB-4705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Gene namesi
Ordered Locus Names:BURPS1710b_A0907Imported
OrganismiBurkholderia pseudomallei (strain 1710b)Imported
Taxonomic identifieri320372 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002700: Chromosome II

Interactioni

Protein-protein interaction databases

STRINGi320372.BURPS1710b_A0907.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2SNMR-A1-113[»]
3UF8X-ray1.50A2-113[»]
3UQBX-ray1.90A2-113[»]
3VAWX-ray1.55A4-113[»]
4DZ2X-ray2.00A/B2-113[»]
4DZ3X-ray2.00A/B2-113[»]
4FN2X-ray1.95A/B2-113[»]
4G50X-ray1.75A/B2-113[»]
4GGQX-ray1.95A/B/C/D2-113[»]
4GIVX-ray2.45A/B2-113[»]
ProteinModelPortaliQ3JK38.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3JK38.

Family & Domainsi

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
KOiK01802.
OMAiQKGKKFD.
OrthoDBiEOG6DRPKW.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3JK38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN
60 70 80 90 100
DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP
110
NATLVFEVEL LDV
Length:113
Mass (Da):11,930
Last modified:November 8, 2005 - v1
Checksum:i10AB26FB56F3F284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000125 Genomic DNA. Translation: ABA51599.1.
RefSeqiYP_336065.1. NC_007435.1.

Genome annotation databases

EnsemblBacteriaiABA51599; ABA51599; BURPS1710b_A0907.
GeneIDi3694107.
KEGGibpm:BURPS1710b_A0907.
PATRICi19242233. VBIBurPse115837_4954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000125 Genomic DNA. Translation: ABA51599.1 .
RefSeqi YP_336065.1. NC_007435.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L2S NMR - A 1-113 [» ]
3UF8 X-ray 1.50 A 2-113 [» ]
3UQB X-ray 1.90 A 2-113 [» ]
3VAW X-ray 1.55 A 4-113 [» ]
4DZ2 X-ray 2.00 A/B 2-113 [» ]
4DZ3 X-ray 2.00 A/B 2-113 [» ]
4FN2 X-ray 1.95 A/B 2-113 [» ]
4G50 X-ray 1.75 A/B 2-113 [» ]
4GGQ X-ray 1.95 A/B/C/D 2-113 [» ]
4GIV X-ray 2.45 A/B 2-113 [» ]
ProteinModelPortali Q3JK38.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320372.BURPS1710b_A0907.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA51599 ; ABA51599 ; BURPS1710b_A0907 .
GeneIDi 3694107.
KEGGi bpm:BURPS1710b_A0907.
PATRICi 19242233. VBIBurPse115837_4954.

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154887.
KOi K01802.
OMAi QKGKKFD.
OrthoDBi EOG6DRPKW.

Enzyme and pathway databases

BioCyci BPSE320372:GBYB-4705-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q3JK38.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Woods D.E., Nierman W.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1710bImported.
  2. "Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Zheng S., Barnwal R., Leeper T., Varani G.
    Submitted (AUG-2010) to the PDB data bank
    Cited for: STRUCTURE BY NMR.
  3. "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins."
    Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., Norville I.H.
    , Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.
    Antimicrob. Agents Chemother. 58:1458-1467(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-113 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ3JK38_BURP1
AccessioniPrimary (citable) accession number: Q3JK38
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3