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Q3JK38

- Q3JK38_BURP1

UniProt

Q3JK38 - Q3JK38_BURP1

Protein

Peptidyl-prolyl cis-trans isomerase

Gene

BURPS1710b_A0907

Organism
Burkholderia pseudomallei (strain 1710b)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511CalciumImported
    Metal bindingi52 – 521Calcium; via carbonyl oxygenImported
    Metal bindingi112 – 1121CalciumImported
    Metal bindingi113 – 1131Calcium; via amide nitrogen and carbonyl oxygenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, RotamaseUniRule annotation

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciBPSE320372:GBYB-4705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
    Gene namesi
    Ordered Locus Names:BURPS1710b_A0907Imported
    OrganismiBurkholderia pseudomallei (strain 1710b)Imported
    Taxonomic identifieri320372 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002700: Chromosome II

    Interactioni

    Protein-protein interaction databases

    STRINGi320372.BURPS1710b_A0907.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L2SNMR-A1-113[»]
    3UF8X-ray1.50A2-113[»]
    3UQBX-ray1.90A2-113[»]
    3VAWX-ray1.55A4-113[»]
    4DZ2X-ray2.00A/B2-113[»]
    4DZ3X-ray2.00A/B2-113[»]
    4FN2X-ray1.95A/B2-113[»]
    4G50X-ray1.75A/B2-113[»]
    4GGQX-ray1.95A/B/C/D2-113[»]
    4GIVX-ray2.45A/B2-113[»]
    ProteinModelPortaliQ3JK38.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3JK38.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    KOiK01802.
    OMAiQKGKKFD.
    OrthoDBiEOG6DRPKW.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3JK38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN    50
    DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP 100
    NATLVFEVEL LDV 113
    Length:113
    Mass (Da):11,930
    Last modified:November 8, 2005 - v1
    Checksum:i10AB26FB56F3F284
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000125 Genomic DNA. Translation: ABA51599.1.
    RefSeqiYP_336065.1. NC_007435.1.

    Genome annotation databases

    EnsemblBacteriaiABA51599; ABA51599; BURPS1710b_A0907.
    GeneIDi3694107.
    KEGGibpm:BURPS1710b_A0907.
    PATRICi19242233. VBIBurPse115837_4954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000125 Genomic DNA. Translation: ABA51599.1 .
    RefSeqi YP_336065.1. NC_007435.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L2S NMR - A 1-113 [» ]
    3UF8 X-ray 1.50 A 2-113 [» ]
    3UQB X-ray 1.90 A 2-113 [» ]
    3VAW X-ray 1.55 A 4-113 [» ]
    4DZ2 X-ray 2.00 A/B 2-113 [» ]
    4DZ3 X-ray 2.00 A/B 2-113 [» ]
    4FN2 X-ray 1.95 A/B 2-113 [» ]
    4G50 X-ray 1.75 A/B 2-113 [» ]
    4GGQ X-ray 1.95 A/B/C/D 2-113 [» ]
    4GIV X-ray 2.45 A/B 2-113 [» ]
    ProteinModelPortali Q3JK38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320372.BURPS1710b_A0907.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA51599 ; ABA51599 ; BURPS1710b_A0907 .
    GeneIDi 3694107.
    KEGGi bpm:BURPS1710b_A0907.
    PATRICi 19242233. VBIBurPse115837_4954.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    KOi K01802.
    OMAi QKGKKFD.
    OrthoDBi EOG6DRPKW.

    Enzyme and pathway databases

    BioCyci BPSE320372:GBYB-4705-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q3JK38.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Woods D.E., Nierman W.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1710bImported.
    2. "Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Zheng S., Barnwal R., Leeper T., Varani G.
      Submitted (AUG-2010) to the PDB data bank
      Cited for: STRUCTURE BY NMR.
    3. "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins."
      Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., Norville I.H.
      , Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.
      Antimicrob. Agents Chemother. 58:1458-1467(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-113 IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiQ3JK38_BURP1
    AccessioniPrimary (citable) accession number: Q3JK38
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3