Q3JE55 (PYRB_NITOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Noc_0365

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321124

Sequences

	Sequence		Length	Mass (Da)
	Q3JE55 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: AD1F6A79A115711A	FASTA	324	35,871
	10 20 30 40 50 60 MSNLQLDQNG QLRHFLSIQG LNRELLTRIL DTAESFSTIG AQHVKKVPLL RGKTIVNLFF 70 80 90 100 110 120 ENSTRTLSTF ELAAKRLSAD VMNLNVRTSS TQKGESLLDT LRSLEAMHCD MFVVRHSDSG 130 140 150 160 170 180 AAYFIARHVP SHVSVINAGD GCHSHPSQAM LDMLTIRRHK GSFPNLRVAI VGDILHSRVA 190 200 210 220 230 240 RSEIHALATL GTGEIRVIAP RTLLPRNVES LGVHIFHDMR AGLKGVDVVI TLRLQRERME 250 260 270 280 290 300 GARLPSEREY FQLYGLTEEK LALARPEAIV MHPGPINRGI EIESAVADGP HSVILEQVSH 310 320 GIAIRMAVMA MTMQIPVPEA KEAR

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed: 16957257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19707 / NCIMB 11848.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000127 Genomic DNA. Translation: ABA56891.1.
RefSeq	YP_342421.1. NC_007484.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q3JE55.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JE55.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3706536.
GenomeReviews	Gene locus Noc_0365 in contig CP000127_GR.
KEGG	noc:Noc_0365.
NMPDR	fig|323261.3.peg.456.
PATRIC	22704448. VBINitOce57959_0468.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q3JE55.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	NOCE323261:NOC_0365-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_NITOC

Accession

Primary (citable) accession number: Q3JE55

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program