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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Noc_0908Imported
OrganismiNitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)Imported
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
Proteomesi
  • UP000006838 Componenti: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi323261.Noc_0908

Structurei

3D structure databases

ProteinModelPortaliQ3JCM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q3JCM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHTDED IRAMLATAGV PDIETLFDEI PADLRTTDFD AVPPGLNEME
60 70 80 90 100
VSRLLQERAA QNRPTVCFAG GGAYQHHIPA AVWEITSRGE YYSAYTPYQA
110 120 130 140 150
EASQGTLQVI YEYQSMMTAL TGMEVSNASI YDGASALGEA VLMAVRLSRR
160 170 180 190 200
GKSSCVLLPA TVHPAYRQVV ATLVGDQGIS LQEISYDFGS GVVEPETLES
210 220 230 240 250
IQKDFAALVI PQPNYFGCLE EVDTLTNWAH ERGALVIGVV NPTSLALLKP
260 270 280 290 300
PGEWGEAGAD IVCGEGQPLG IPLASGGPYF GFMACKQAHV RQLPGRIVGR
310 320 330 340 350
TVDLESKPGY TLTLQAREQH IRRSKATSNI CTNQGLMVTA ATLYMALLGP
360 370 380 390 400
QGLAQVATAC HANTMALVKR LTALPGVEQV FEKPFFHEAV LRFPVPASRV
410 420 430 440 450
LSVLGQGGVL AGVKLEQAYP ELNDTLLVCA TELRNEEDIE FYVRELTAAL

AG
Length:452
Mass (Da):48,712
Last modified:November 8, 2005 - v1
Checksum:i1A63F957578F4370
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA57420.1
RefSeqiWP_002809013.1, NC_007484.1

Genome annotation databases

EnsemblBacteriaiABA57420; ABA57420; Noc_0908
KEGGinoc:Noc_0908

Similar proteinsi

Entry informationi

Entry nameiQ3JCM6_NITOC
AccessioniPrimary (citable) accession number: Q3JCM6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health