Reviewed, UniProtKB/Swiss-Prot Q3JCI7 (CCMA_NITOC)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	Noc_0948

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) Probable.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Cytochrome c biogenesis ATP-binding export protein ccmA HAMAP MF_01707		PRO_0000271936
Regions
	Domain	18 – 216	199	ABC transporter
	Nucleotide binding	50 – 57	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3JCI7-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: D42F690F6972959C	FASTA	216	23,734
	10 20 30 40 50 60 MGKDNKKQTM LDQAQPRLQV EGLAGRRGER LLFKNMNFTV DMGEVLEVSG HNGSGKTTLL 70 80 90 100 110 120 RLLCGLLLPE EGTLQWRGQP INKIRPLYHS ELSYVGHTDA IKGELTAHEN LMIAGALNGG 130 140 150 160 170 180 GIDPEQALER VGLTTIRELP GRFLSAGQRR RLALARLLVN RAWLWLLDEP FTALDKVAIR 190 200 210 TIATLLEEHA AAGGIAIFTS HHAINIAHAR TLEISA

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed: 16957257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000127 Genomic DNA. Translation: ABA57459.1.
RefSeq	YP_342989.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3JCI7.
Genome annotation databases
GeneID	3707359.
GenomeReviews	Gene locus Noc_0948 in contig CP000127_GR.
KEGG	noc:Noc_0948.
NMPDR	fig|323261.3.peg.1143.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3JCI7.
OMA	TCIRDER.
Enzyme and pathway databases
BioCyc	NOCE323261:NOC_0948-MON.
Family and domain databases
HAMAP	MF_01707. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_NITOC

Accession

Primary (citable) accession number: Q3JCI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)