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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Noc_1182
OrganismiNitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
Proteomesi
  • UP000006838 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002583741 – 358Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST358

Proteomic databases

PRIDEiQ3JBW2

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_1182

Structurei

3D structure databases

ProteinModelPortaliQ3JBW2
SMRiQ3JBW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q3JBW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKKLPPSS HSPLSYRDAG VDIDAGNQLI QRIKPAANRT TRPGVLTSLG
60 70 80 90 100
GFGSLFELPI HRYQHPVLVA GTDGVGTKLK LAIQLNRHDS IGIDLVAMCA
110 120 130 140 150
NDIIVQGAEP LFFLDYYATG RLEVDIAAEI IEGIAHGCEL AGVALVGGET
160 170 180 190 200
AEMPGIYQAG DYDLAGFCVG VVEKERLIDG SQVQAGDHLI GIASSGPHAN
210 220 230 240 250
GYSLIRKILE RSRYSLNSPL ADQTLGDALL TPTRIYVKPL LQLLEVIEIH
260 270 280 290 300
ALAHITGGGL PENLPRVLPP MLSAEIDTSR WPRLPIFDWL QREGNLSEQE
310 320 330 340 350
LYRTFNCGIG MVVCVDQADT EQALEFLKDR GESAWLIGRI VPQTSDGQRV

AFNTGNPL
Length:358
Mass (Da):38,748
Last modified:November 8, 2005 - v1
Checksum:i79875D6A00A6DE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA57684.1
RefSeqiWP_002811198.1, NC_007484.1

Genome annotation databases

EnsemblBacteriaiABA57684; ABA57684; Noc_1182
KEGGinoc:Noc_1182

Similar proteinsi

Entry informationi

Entry nameiPUR5_NITOC
AccessioniPrimary (citable) accession number: Q3JBW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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