Q3JBW2 (PUR5_NITOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Noc_1182

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus › Nitrosococcus oceani

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_0000258374

Sequences

	Sequence		Length	Mass (Da)
	Q3JBW2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 79875D6A00A6DE68	FASTA	358	38,748
	10 20 30 40 50 60 MSKKKLPPSS HSPLSYRDAG VDIDAGNQLI QRIKPAANRT TRPGVLTSLG GFGSLFELPI 70 80 90 100 110 120 HRYQHPVLVA GTDGVGTKLK LAIQLNRHDS IGIDLVAMCA NDIIVQGAEP LFFLDYYATG 130 140 150 160 170 180 RLEVDIAAEI IEGIAHGCEL AGVALVGGET AEMPGIYQAG DYDLAGFCVG VVEKERLIDG 190 200 210 220 230 240 SQVQAGDHLI GIASSGPHAN GYSLIRKILE RSRYSLNSPL ADQTLGDALL TPTRIYVKPL 250 260 270 280 290 300 LQLLEVIEIH ALAHITGGGL PENLPRVLPP MLSAEIDTSR WPRLPIFDWL QREGNLSEQE 310 320 330 340 350 LYRTFNCGIG MVVCVDQADT EQALEFLKDR GESAWLIGRI VPQTSDGQRV AFNTGNPL

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19707 / NCIMB 11848.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000127 Genomic DNA. Translation: ABA57684.1.
RefSeq	YP_343214.1. NC_007484.1.
3D structure databases
ProteinModelPortal	Q3JBW2.
SMR	Q3JBW2. Positions 12-350.
ModBase	Search...
Protein-protein interaction databases
STRING	323261.Noc_1182.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA57684; ABA57684; Noc_1182.
GeneID	3706756.
KEGG	noc:Noc_1182.
PATRIC	22706338. VBINitOce57959_1398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229091.
KO	K01933.
OMA	PRVLPKH.
ProtClustDB	PRK05385.
Enzyme and pathway databases
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_NITOC

Accession

Primary (citable) accession number: Q3JBW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program