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Q3JAC1

- LPXB_NITOC

UniProt

Q3JAC1 - LPXB_NITOC

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciNOCE323261:GCI3-1782-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Noc_1753
OrganismiNitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
ProteomesiUP000006838: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Lipid-A-disaccharide synthasePRO_0000255203Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_1753.

Structurei

3D structure databases

ProteinModelPortaliQ3JAC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3JAC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENSAPLVAI VAGEASGDQH AAHLIREVKK IAPGVRFGGI AGPQMRAAGV
60 70 80 90 100
EPLFDSSRLA VVGLVEVLSH LNEIYGAMQK MRHFLEEKHP DLLILVDYPE
110 120 130 140 150
FNLRLAKRAK TLGIKVLYYI SPQVWAWRQY RVHQIGQVVD MMAVVLPFEV
160 170 180 190 200
PFYEQAGVPV NFVGHPLQHE VKSKFNRNEA VVEFGFNPCC KTLGLLPGSR
210 220 230 240 250
HSEIKRLLPV LLEAAERIYS EEPEIQYLLP LAATLKEIDL APYLKGYRLP
260 270 280 290 300
LRVIPDRSYD VMAACDAMVA ASGTVTLEAA LMGVPLVVIY KMNSLSYWMG
310 320 330 340 350
RLLIKVDHIA LCNIIAGEGV APELIQQDAS PERIALEALN LLRDKERRQT
360 370 380
MQQKFYAIKH KLGAGAQRTI AELTVAMLEG ENLGRAS
Length:387
Mass (Da):43,005
Last modified:November 8, 2005 - v1
Checksum:i67CD25C95187726C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA. Translation: ABA58225.1.
RefSeqiYP_343755.1. NC_007484.1.

Genome annotation databases

EnsemblBacteriaiABA58225; ABA58225; Noc_1753.
GeneIDi3705014.
KEGGinoc:Noc_1753.
PATRICi22707718. VBINitOce57959_2078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA. Translation: ABA58225.1 .
RefSeqi YP_343755.1. NC_007484.1.

3D structure databases

ProteinModelPortali Q3JAC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323261.Noc_1753.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA58225 ; ABA58225 ; Noc_1753 .
GeneIDi 3705014.
KEGGi noc:Noc_1753.
PATRICi 22707718. VBINitOce57959_2078.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci NOCE323261:GCI3-1782-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707."
    Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B.
    Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19707 / NCIMB 11848.

Entry informationi

Entry nameiLPXB_NITOC
AccessioniPrimary (citable) accession number: Q3JAC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3