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Q3J9J7

- GCH4_NITOC

UniProt

Q3J9J7 - GCH4_NITOC

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciNOCE323261:GCI3-2072-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Noc_2039
OrganismiNitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
ProteomesiUP000006838: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267GTP cyclohydrolase FolE2PRO_0000289500Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_2039.

Structurei

3D structure databases

ProteinModelPortaliQ3J9J7.
SMRiQ3J9J7. Positions 23-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3J9J7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPIVPAVER PIEDVQAKAD ERQIAINKVG IKDIRHPVRV SDRNGGEQHT
60 70 80 90 100
VANFNMYVDL PHHFKGTHMS RFVEILNQHE HEITVRSFRE MLREMNHRLQ
110 120 130 140 150
AESGHIEMVF PYFVTKQAPV SKVQSLMDYQ VTFIGEIKGD KPQITVKVVV
160 170 180 190 200
PVTSLCPCSK QISDYGAHNQ RSHVTVAVRI EGFIWLEDII DLVEEEASCE
210 220 230 240 250
IYGLLKRPDE KYVTERAYDN PKFVEDMVRD VAARLNQDDR VSAYRVESEN
260
FESIHNHSAY AMIEREK
Length:267
Mass (Da):30,856
Last modified:November 8, 2005 - v1
Checksum:i270C6365E74C1E24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA58499.1.
RefSeqiYP_344029.1. NC_007484.1.

Genome annotation databases

EnsemblBacteriaiABA58499; ABA58499; Noc_2039.
GeneIDi3705190.
KEGGinoc:Noc_2039.
PATRICi22708396. VBINitOce57959_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA58499.1 .
RefSeqi YP_344029.1. NC_007484.1.

3D structure databases

ProteinModelPortali Q3J9J7.
SMRi Q3J9J7. Positions 23-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323261.Noc_2039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA58499 ; ABA58499 ; Noc_2039 .
GeneIDi 3705190.
KEGGi noc:Noc_2039.
PATRICi 22708396. VBINitOce57959_2413.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci NOCE323261:GCI3-2072-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707."
    Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B.
    Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19707 / NCIMB 11848.

Entry informationi

Entry nameiGCH4_NITOC
AccessioniPrimary (citable) accession number: Q3J9J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3