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Protein

Argininosuccinate synthase

Gene

argG

Organism
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei88 – 881CitrullineUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei179 – 1791CitrullineUniRule annotation
Binding sitei188 – 1881CitrullineUniRule annotation
Binding sitei264 – 2641CitrullineUniRule annotation
Binding sitei276 – 2761CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNOCE323261:GCI3-2141-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Noc_2108
OrganismiNitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
ProteomesiUP000006838 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Argininosuccinate synthasePRO_0000263944Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi323261.Noc_2108.

Structurei

3D structure databases

ProteinModelPortaliQ3J9C8.
SMRiQ3J9C8. Positions 6-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J9C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIKKVVLA YSGGLDTSVI LKWLQETYDC EVVTFTADIG QGEEVAPARA
60 70 80 90 100
KAETLGVKEI YIEDLREEFC RDYVFPMFRA NTLYEGEYLL GTSIARPLIA
110 120 130 140 150
KRLAEIASAT GADAVAHGAT GKGNDQVRFE LGVYALQPDI QVIAPWREWD
160 170 180 190 200
LTSREKLLAY AETHGIPVEG KRGGRSPYSM DANLLHISYE GGPLEDPWFE
210 220 230 240 250
PEESMWRWTT SPEASADQAA YLELDYRCGD IVAINGEVLS PAKVLESLNQ
260 270 280 290 300
LGSKHGIGRL DLVENRYVGM KSRGCYETPA GTIMLKAHRA LESLTLDREV
310 320 330 340 350
THLKDELMPR YANLIYNGYW WSPERSLLQQ LIDGSQVTVN GTVRLKLYKG
360 370 380 390 400
NVVVVGRRSE TDSLFAPEIA TFEDDAGAYN QQDAEGFIKL NALRLRIEAL

KKQTH
Length:405
Mass (Da):45,219
Last modified:November 8, 2005 - v1
Checksum:iB747B1A9617AB876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA. Translation: ABA58568.1.
RefSeqiWP_002809303.1. NC_007484.1.
YP_344098.1. NC_007484.1.

Genome annotation databases

EnsemblBacteriaiABA58568; ABA58568; Noc_2108.
KEGGinoc:Noc_2108.
PATRICi22708550. VBINitOce57959_2490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA. Translation: ABA58568.1.
RefSeqiWP_002809303.1. NC_007484.1.
YP_344098.1. NC_007484.1.

3D structure databases

ProteinModelPortaliQ3J9C8.
SMRiQ3J9C8. Positions 6-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323261.Noc_2108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA58568; ABA58568; Noc_2108.
KEGGinoc:Noc_2108.
PATRICi22708550. VBINitOce57959_2490.

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciNOCE323261:GCI3-2141-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707."
    Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B.
    Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19707 / NCIMB 11848.

Entry informationi

Entry nameiASSY_NITOC
AccessioniPrimary (citable) accession number: Q3J9C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 8, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.