Reviewed, UniProtKB/Swiss-Prot Q3J953 (NAGZ_NITOC)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	Noc_2183

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Beta-hexosaminidase HAMAP MF_00364		PRO_0000234918
Sites
	Active site	252	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3J953-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 77F833A74F915E20	FASTA	341	37,327
	10 20 30 40 50 60 MTLGPLMIDL KGVTLDSEER AWLGHSWVGG VILFSRNYES PEQIAALIKA VHALKEPRLL 70 80 90 100 110 120 VAVDHEGGRV QRFRDGFTLL PPASLLGKLY DRDQRQAQRL AMITGWLMAV ELRAVGVDFS 130 140 150 160 170 180 FSPVLDLDRG VSAVIGDRAF HGEPDAVIAL ARAYIRGMAW AGMAAVGKHF PGHGSVVADS 190 200 210 220 230 240 HTALPVDKRS WRQIREGDLL PFEHLARAGL PAVMPAHVRY ASVDSRPVGF SPFWLETVLR 250 260 270 280 290 300 GQLGFQGAII SDDLSMAGAA EVGDMSARMQ AALSAGCDMA LVCNDPDGYA LLLDELKGDP 310 320 330 340 YPQTSPRLLR LYGRYPLTRS QLYHNPAWQR AVQMLAAYGE F

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed: 16957257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000127 Genomic DNA. Translation: ABA58643.1.
RefSeq	YP_344173.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3J953.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Genome annotation databases
GeneID	3705219.
GenomeReviews	Gene locus Noc_2183 in contig CP000127_GR.
KEGG	noc:Noc_2183.
NMPDR	fig|323261.3.peg.2809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3J953.
OMA	AKEAGWQ.
Enzyme and pathway databases
BioCyc	NOCE323261:NOC_2183-MON.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_NITOC

Accession

Primary (citable) accession number: Q3J953

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)