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Q3J7S8

- SYL_NITOC

UniProt

Q3J7S8 - SYL_NITOC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNOCE323261:GCI3-2712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Noc_2665
OrganismiNitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
ProteomesiUP000006838: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_1000009381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_2665.

Structurei

3D structure databases

ProteinModelPortaliQ3J7S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J7S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEHYQAIQI EAEAQAYWEQ HQSFRASEDP SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMRG RNVLQPMGWD AFGLPAENAA IQNRVPPAQW
110 120 130 140 150
TYENIDHMRR QLKRLGFAYD WSRELATCQP DYYRWEQWLF TKLFAKGLVY
160 170 180 190 200
KKTALVNWDP VDQTVLANEQ VIDGRGWRSG ALVERREIPQ WFLKITAYGE
210 220 230 240 250
ELLTALDGLT GWPEQVRAMQ RNWIGRSEGI EVQFHVEGKE ALAVFTTRPD
260 270 280 290 300
TLMGVTFVSV AAEHPLAREA ATSNPALAAF LEQCQRTATS EAILETLEKE
310 320 330 340 350
GMDTGFKAIH PITGEAVPIW VANFVLMGYG TGAVMAVPAH DQRDYEFAKV
360 370 380 390 400
YGLPIQQVIA PKDDQASCNL EQSAFVEKGL LINSGDFTGL DFDQAFAAIA
410 420 430 440 450
EHLERGGKGQ RRVNYRLRDW GVSRQRYWGA PIPIVHCLHC GAIPVPEEDL
460 470 480 490 500
PVVLPERVRF DGIRSPLKQL PEFYQTSCPQ CGGQAKRETD TFDTFFESSW
510 520 530 540 550
YYARYCCPDN NATMVDERGD YWLPVDQYIG GIEHAVLHLL YARFFHKVMR
560 570 580 590 600
DMGLVRSDEP FTHLLTQGMV LKDGAKMSKS KGNTVDPQAL IEHYGADTAR
610 620 630 640 650
LFIMFAAPPE QSLEWSESGV EGAHRFLKRL WRIVAAHVEQ DPKAALTLKV
660 670 680 690 700
KDLNSEQKSF RAKVHETIAK ASDDIGRRYT FNTAIAAIME LMNALAKFDD
710 720 730 740 750
SSPQGQAIRQ EALEAVVLLL SPITPHICHR LWQELGHREA IIGVPWPEAD
760 770 780 790 800
PDALAKESIE LVVQVNGKRR GQITVAVQAP REEIEGQAQA EPNVQRFIEG
810
KTVQKVIIVP NRLVNLVVS
Length:819
Mass (Da):92,714
Last modified:November 8, 2005 - v1
Checksum:iE35A47C5CB8B559F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA59118.1.
RefSeqiYP_344648.1. NC_007484.1.

Genome annotation databases

EnsemblBacteriaiABA59118; ABA59118; Noc_2665.
GeneIDi3705162.
KEGGinoc:Noc_2665.
PATRICi22709796. VBINitOce57959_3100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA59118.1 .
RefSeqi YP_344648.1. NC_007484.1.

3D structure databases

ProteinModelPortali Q3J7S8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323261.Noc_2665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA59118 ; ABA59118 ; Noc_2665 .
GeneIDi 3705162.
KEGGi noc:Noc_2665.
PATRICi 22709796. VBINitOce57959_3100.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NOCE323261:GCI3-2712-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707."
    Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B.
    Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19707 / NCIMB 11848.

Entry informationi

Entry nameiSYL_NITOC
AccessioniPrimary (citable) accession number: Q3J7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3