Reviewed, UniProtKB/Swiss-Prot Q3J7H2 (HIS82_NITOC)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Noc_2777

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153403
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3J7H2-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 95383D042F42CE3A	FASTA	360	40,218
	10 20 30 40 50 60 MTKDRVAQWI RPEIQRLSAY RVADAADLIK LDAMENPYTW SPELIEAWLE RLRQVSVNRY 70 80 90 100 110 120 PDPQARSLKL RLRQYLALPE DMEMILGNGS DELIQMVLLA VAGPGRSVVA PEPTFVMYRQ 130 140 150 160 170 180 IAALLGLQYQ GVALREDFSL DLPAMLQVIR ERVPAVVFIA YPNNPTGNLF SAEELQAIIE 190 200 210 220 230 240 ASPGLVIVDE AYSVFAGETF MPRLEDYDHL LVMRTLSKIG LAGLRLGMLM GNPAWIKELE 250 260 270 280 290 300 KVRLPYNINQ LTQVSAEFAL EQPGGLDEQA RLICKARAQL QRALQQLPGI QVYPSDANFI 310 320 330 340 350 360 LFRTPPHQAE AIFTAIKERG VLIKNLSGQG GLLTDCLRVT VGTADENHAF LKALKAGRKN

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed: 16957257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000127 Genomic DNA. Translation: ABA59224.1.
RefSeq	YP_344754.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3J7H2.
Genome annotation databases
GeneID	3705507.
GenomeReviews	Gene locus Noc_2777 in contig CP000127_GR.
KEGG	noc:Noc_2777.
NMPDR	fig|323261.3.peg.2925.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3J7H2.
OMA	RIQTIEH.
Enzyme and pathway databases
BioCyc	NOCE323261:NOC_2777-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_NITOC

Accession

Primary (citable) accession number: Q3J7H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)