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Q3J7H1

- HISX_NITOC

UniProt

Q3J7H1 - HISX_NITOC

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Protein

Histidinol dehydrogenase

Gene
hisD, Noc_2778
Organism
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei330 – 3301Proton acceptor By similarity
Active sitei331 – 3311Proton acceptor By similarity
Binding sitei331 – 3311Substrate By similarity
Metal bindingi364 – 3641Zinc By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei418 – 4181Substrate By similarity
Metal bindingi423 – 4231Zinc By similarity
Binding sitei423 – 4231Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNOCE323261:GCI3-2826-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Noc_2778
OrganismiNitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
ProteomesiUP000006838: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenaseUniRule annotationPRO_0000135804Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_2778.

Structurei

3D structure databases

ProteinModelPortaliQ3J7H1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J7H1-1 [UniParc]FASTAAdd to Basket

« Hide

MVEMTRLDIA QGDFWLCLEQ RLAWEGVADE TVVATVREIL KAIRCRGDEA    50
LLEYTQRFDG LEIARAPELE IPTSRLQAAL TAISREQREA LQVAAERITT 100
YHRHQKQESW SYTEPDGTLL GQQVRPLDRV GLYVPGGKAA YPSSVLMNAL 150
PAKVAGVSEL IMVVPTPKGE MNDLVLGAAA IAGVDRVFTV GGAQAVAALA 200
FGTESVPRVD KIVGPGNMYV ATAKSMVFGQ VGIDMIAGPS EILVLCDGKT 250
DPEWIAMDLF SQAEHDEAAQ AILLSPDGVF LDKVTEAMAR LLPTLERQEV 300
IANSLRSRGT LIKVENLDQA LEVINFIAPE HLELSVEDPQ ALASRVRHAG 350
AIFMGRYTAE AIGDYCAGSN HVLPTSRTAR FSSPLGVYDF QKRSSLIQCS 400
PQGSQTLGRV ASVLARGEGL TAHARSAEYR LKG 433
Length:433
Mass (Da):46,883
Last modified:November 8, 2005 - v1
Checksum:iD2DB66A4EF3BEA77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA59225.1.
RefSeqiWP_002812729.1. NC_007484.1.
YP_344755.1. NC_007484.1.

Genome annotation databases

EnsemblBacteriaiABA59225; ABA59225; Noc_2778.
GeneIDi3705508.
KEGGinoc:Noc_2778.
PATRICi22710052. VBINitOce57959_3227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000127 Genomic DNA. Translation: ABA59225.1 .
RefSeqi WP_002812729.1. NC_007484.1.
YP_344755.1. NC_007484.1.

3D structure databases

ProteinModelPortali Q3J7H1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323261.Noc_2778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA59225 ; ABA59225 ; Noc_2778 .
GeneIDi 3705508.
KEGGi noc:Noc_2778.
PATRICi 22710052. VBINitOce57959_3227.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci NOCE323261:GCI3-2826-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707."
    Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B.
    Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19707 / NCIMB 11848.

Entry informationi

Entry nameiHISX_NITOC
AccessioniPrimary (citable) accession number: Q3J7H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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