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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase 1 (hisC1)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133NADUniRule annotation1
Binding sitei194NADUniRule annotation1
Binding sitei217NADUniRule annotation1
Binding sitei240SubstrateUniRule annotation1
Metal bindingi262ZincUniRule annotation1
Binding sitei262SubstrateUniRule annotation1
Metal bindingi265ZincUniRule annotation1
Binding sitei265SubstrateUniRule annotation1
Active sitei330Proton acceptorUniRule annotation1
Active sitei331Proton acceptorUniRule annotation1
Binding sitei331SubstrateUniRule annotation1
Metal bindingi364ZincUniRule annotation1
Binding sitei364SubstrateUniRule annotation1
Binding sitei418SubstrateUniRule annotation1
Metal bindingi423ZincUniRule annotation1
Binding sitei423SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Noc_2778
OrganismiNitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
Proteomesi
  • UP000006838 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358041 – 433Histidinol dehydrogenaseAdd BLAST433

Proteomic databases

PRIDEiQ3J7H1

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_2778

Structurei

3D structure databases

ProteinModelPortaliQ3J7H1
SMRiQ3J7H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3J7H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEMTRLDIA QGDFWLCLEQ RLAWEGVADE TVVATVREIL KAIRCRGDEA
60 70 80 90 100
LLEYTQRFDG LEIARAPELE IPTSRLQAAL TAISREQREA LQVAAERITT
110 120 130 140 150
YHRHQKQESW SYTEPDGTLL GQQVRPLDRV GLYVPGGKAA YPSSVLMNAL
160 170 180 190 200
PAKVAGVSEL IMVVPTPKGE MNDLVLGAAA IAGVDRVFTV GGAQAVAALA
210 220 230 240 250
FGTESVPRVD KIVGPGNMYV ATAKSMVFGQ VGIDMIAGPS EILVLCDGKT
260 270 280 290 300
DPEWIAMDLF SQAEHDEAAQ AILLSPDGVF LDKVTEAMAR LLPTLERQEV
310 320 330 340 350
IANSLRSRGT LIKVENLDQA LEVINFIAPE HLELSVEDPQ ALASRVRHAG
360 370 380 390 400
AIFMGRYTAE AIGDYCAGSN HVLPTSRTAR FSSPLGVYDF QKRSSLIQCS
410 420 430
PQGSQTLGRV ASVLARGEGL TAHARSAEYR LKG
Length:433
Mass (Da):46,883
Last modified:November 8, 2005 - v1
Checksum:iD2DB66A4EF3BEA77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA59225.1
RefSeqiWP_002812729.1, NC_007484.1

Genome annotation databases

EnsemblBacteriaiABA59225; ABA59225; Noc_2778
KEGGinoc:Noc_2778

Similar proteinsi

Entry informationi

Entry nameiHISX_NITOC
AccessioniPrimary (citable) accession number: Q3J7H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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