Q3J7B5 (UPPP_NITOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Noc_2835

Organism

Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) [Complete proteome] [HAMAP]

Taxonomic identifier

323261 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus › Nitrosococcus oceani

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000227622
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 61	23	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3J7B5 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: CDB16BAE6EA5C99A	FASTA	265	28,766
	10 20 30 40 50 60 MDFIHILALA ILQGLTEFLP ISSSAHLILL PVLAGWTDQG LAFDVAVHLG TLVAVISYFR 70 80 90 100 110 120 LELARMARDW LQSLAAGQQQ GESRLAWAVL LGTLPVGLVG IMLTETTQEA LRSPLIIAWS 130 140 150 160 170 180 TVGFGFLLAY ADWAGKQQRN EHTLTWRDIL FIGLAQALAL IPGTSRSGIT ITAGLMLGLT 190 200 210 220 230 240 REGAARFSFL LAIPVILLAG GLAALDLLNH TETVDWNALA LGALISGLCA YACIHYFFKF 250 260 LQRIGMLPFA VYRLLLGALL FYLFS

References

[1]

"Complete genome sequence of the marine, chemolithoautotrophic, ammonia-oxidizing bacterium Nitrosococcus oceani ATCC 19707." Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J., Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T., Vergez L.M., Ward B.B. Appl. Environ. Microbiol. 72:6299-6315(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19707 / NCIMB 11848.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000127 Genomic DNA. Translation: ABA59281.1.
RefSeq	YP_344811.1. NC_007484.1.
3D structure databases
ProteinModelPortal	Q3J7B5.
ModBase	Search...
Protein-protein interaction databases
STRING	323261.Noc_2835.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA59281; ABA59281; Noc_2835.
GeneID	3705526.
KEGG	noc:Noc_2835.
PATRIC	22710172. VBINitOce57959_3287.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HLAIFTA.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_NITOC

Accession

Primary (citable) accession number: Q3J7B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program