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Protein

Transcriptional regulator AcuR

Gene

acuR

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A transcriptional repressor for its operon. Probably binds to 2 operator sequences in the promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 68H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator AcuR
Gene namesi
Name:acuR
Ordered Locus Names:RHOS4_00080
ORF Names:RSP_1435
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Pathology & Biotechi

Disruption phenotypei

Loss of repression of its operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004206191 – 219Transcriptional regulator AcuRAdd BLAST219

Expressioni

Inductioni

Strongly induced by acrylate, the operon product (20-fold), and dimethlysulfonioproprionate, the operon substrate (DMSP, 10-fold). Part of the acuR-acuI-dddL operon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1435.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 27Combined sources3
Helixi28 – 42Combined sources15
Turni45 – 47Combined sources3
Helixi50 – 57Combined sources8
Helixi61 – 67Combined sources7
Helixi71 – 94Combined sources24
Helixi101 – 117Combined sources17
Turni118 – 121Combined sources4
Helixi126 – 132Combined sources7
Helixi134 – 136Combined sources3
Helixi141 – 164Combined sources24
Turni165 – 167Combined sources3
Helixi175 – 196Combined sources22
Helixi200 – 209Combined sources10
Helixi210 – 212Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BRUX-ray2.30A/B1-219[»]
ProteinModelPortaliQ3J6K8.
SMRiQ3J6K8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3J6K8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 86HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108WUH. Bacteria.
ENOG4111IYW. LUCA.
HOGENOMiHOG000161263.
KOiK16137.
OMAiPEYHCFI.
OrthoDBiPOG091H02BD.
PhylomeDBiQ3J6K8.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF16925. TetR_C_13. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J6K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTDTPPSV PQKPRRGRPR GAPDASLAHQ SLIRAGLEHL TEKGYSSVGV
60 70 80 90 100
DEILKAARVP KGSFYHYFRN KADFGLALIE AYDTYFARLL DQAFLDGSLA
110 120 130 140 150
PLARLRLFTR MAEEGMARHG FRRGCLVGNL GQEMGALPDD FRAALIGVLE
160 170 180 190 200
TWQRRTAQLF REAQACGELS ADHDPDALAE AFWIGWEGAI LRAKLELRPD
210
PLHSFTRTFG RHFVTRTQE
Length:219
Mass (Da):24,505
Last modified:November 8, 2005 - v1
Checksum:i28AEC9B393D8BA38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA77576.1.
RefSeqiWP_011336736.1. NZ_AKVW01000001.1.
YP_351477.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA77576; ABA77576; RSP_1435.
GeneIDi3718802.
KEGGirsp:RSP_1435.
PATRICi23149787. VBIRhoSph57909_0299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA77576.1.
RefSeqiWP_011336736.1. NZ_AKVW01000001.1.
YP_351477.1. NC_007493.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BRUX-ray2.30A/B1-219[»]
ProteinModelPortaliQ3J6K8.
SMRiQ3J6K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_1435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA77576; ABA77576; RSP_1435.
GeneIDi3718802.
KEGGirsp:RSP_1435.
PATRICi23149787. VBIRhoSph57909_0299.

Phylogenomic databases

eggNOGiENOG4108WUH. Bacteria.
ENOG4111IYW. LUCA.
HOGENOMiHOG000161263.
KOiK16137.
OMAiPEYHCFI.
OrthoDBiPOG091H02BD.
PhylomeDBiQ3J6K8.

Miscellaneous databases

EvolutionaryTraceiQ3J6K8.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF16925. TetR_C_13. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACUR_RHOS4
AccessioniPrimary (citable) accession number: Q3J6K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.