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Protein

Cytochrome c oxidase subunit 2

Gene

coxII

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi252CopperCombined sources1
Metal bindingi254Copper; via carbonyl oxygenCombined sources1
Metal bindingi256CopperCombined sources1
Metal bindingi260Copper; via pros nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxIIImported
ORF Names:RSP_1826Imported
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)Imported
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 81HelicalSequence analysisAdd BLAST23
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500422645126 – 303Cytochrome c oxidase subunit 2Sequence analysisAdd BLAST278

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1826.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60B/D30-281[»]
3OMAX-ray2.30B/D30-281[»]
3OMIX-ray2.15B/D30-281[»]
3OMNX-ray2.15B/D30-281[»]
ProteinModelPortaliQ3J5G0.
SMRiQ3J5G0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3J5G0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 130COX2_TMInterPro annotationAdd BLAST96
Domaini131 – 281COX2_CUAInterPro annotationAdd BLAST151

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000264988.
KOiK02275.
OMAiFMPIAIR.
OrthoDBiPOG091H05L4.
PhylomeDBiQ3J5G0.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J5G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV
60 70 80 90 100
ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL
110 120 130 140 150
EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP
160 170 180 190 200
DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV
210 220 230 240 250
PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG
260 270 280 290 300
QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV

SVE
Length:303
Mass (Da):32,931
Last modified:November 8, 2005 - v1
Checksum:i2F363ADA39EFEBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA77974.1.
RefSeqiWP_011337012.1. NZ_AKVW01000001.1.
YP_351875.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA77974; ABA77974; RSP_1826.
GeneIDi3719073.
KEGGirsp:RSP_1826.
PATRICi23150624. VBIRhoSph57909_0712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA77974.1.
RefSeqiWP_011337012.1. NZ_AKVW01000001.1.
YP_351875.1. NC_007493.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60B/D30-281[»]
3OMAX-ray2.30B/D30-281[»]
3OMIX-ray2.15B/D30-281[»]
3OMNX-ray2.15B/D30-281[»]
ProteinModelPortaliQ3J5G0.
SMRiQ3J5G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_1826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA77974; ABA77974; RSP_1826.
GeneIDi3719073.
KEGGirsp:RSP_1826.
PATRICi23150624. VBIRhoSph57909_0712.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000264988.
KOiK02275.
OMAiFMPIAIR.
OrthoDBiPOG091H05L4.
PhylomeDBiQ3J5G0.

Miscellaneous databases

EvolutionaryTraceiQ3J5G0.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3J5G0_RHOS4
AccessioniPrimary (citable) accession number: Q3J5G0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.