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Q3J5G0

- Q3J5G0_RHOS4

UniProt

Q3J5G0 - Q3J5G0_RHOS4

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Protein

Cytochrome c oxidase subunit 2

Gene

coxII

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Copper A.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521CopperImported
Metal bindingi254 – 2541Copper; via carbonyl oxygenImported
Metal bindingi256 – 2561CopperImported
Metal bindingi260 – 2601Copper; via pros nitrogenImported

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationImported, Metal-bindingUniRule annotationImported

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxIIImported
ORF Names:RSP_1826Imported
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)Imported
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1826.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60B/D30-281[»]
3OMAX-ray2.30B/D30-281[»]
3OMIX-ray2.15B/D30-281[»]
3OMNX-ray2.15B/D30-281[»]
ProteinModelPortaliQ3J5G0.
SMRiQ3J5G0. Positions 30-289.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3J5G0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
KOiK02275.
OMAiDHALMIV.
OrthoDBiEOG68SVXT.
PhylomeDBiQ3J5G0.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J5G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV
60 70 80 90 100
ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL
110 120 130 140 150
EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP
160 170 180 190 200
DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV
210 220 230 240 250
PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG
260 270 280 290 300
QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV

SVE
Length:303
Mass (Da):32,931
Last modified:November 8, 2005 - v1
Checksum:i2F363ADA39EFEBF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA77974.1.
RefSeqiWP_011337012.1. NZ_AKVW01000001.1.
YP_351875.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA77974; ABA77974; RSP_1826.
GeneIDi3719073.
KEGGirsp:RSP_1826.
PATRICi23150624. VBIRhoSph57909_0712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA77974.1 .
RefSeqi WP_011337012.1. NZ_AKVW01000001.1.
YP_351875.1. NC_007493.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OM3 X-ray 2.60 B/D 30-281 [» ]
3OMA X-ray 2.30 B/D 30-281 [» ]
3OMI X-ray 2.15 B/D 30-281 [» ]
3OMN X-ray 2.15 B/D 30-281 [» ]
ProteinModelPortali Q3J5G0.
SMRi Q3J5G0. Positions 30-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272943.RSP_1826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA77974 ; ABA77974 ; RSP_1826 .
GeneIDi 3719073.
KEGGi rsp:RSP_1826.
PATRICi 23150624. VBIRhoSph57909_0712.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
KOi K02275.
OMAi DHALMIV.
OrthoDBi EOG68SVXT.
PhylomeDBi Q3J5G0.

Enzyme and pathway databases

BioCyci RSPH272943:GJAS-419-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q3J5G0.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158Imported.
  2. "Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump."
    Liu J., Qin L., Ferguson-Miller S.
    Proc. Natl. Acad. Sci. U.S.A. 108:1284-1289(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 30-281 IN COMPLEX WITH COPPER.

Entry informationi

Entry nameiQ3J5G0_RHOS4
AccessioniPrimary (citable) accession number: Q3J5G0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3