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Q3J5G0

- Q3J5G0_RHOS4

UniProt

Q3J5G0 - Q3J5G0_RHOS4

Protein

Cytochrome c oxidase subunit 2

Gene

coxII

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi252 – 2521CopperImported
    Metal bindingi254 – 2541Copper; via carbonyl oxygenImported
    Metal bindingi256 – 2561CopperImported
    Metal bindingi260 – 2601Copper; via pros nitrogenImported

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Electron transport, Respiratory chainUniRule annotation, Transport

    Keywords - Ligandi

    CopperUniRule annotationImported, Metal-bindingUniRule annotationImported

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
    Gene namesi
    Name:coxIIImported
    ORF Names:RSP_1826Imported
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)Imported
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    STRINGi272943.RSP_1826.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OM3X-ray2.60B/D30-281[»]
    3OMAX-ray2.30B/D30-281[»]
    3OMIX-ray2.15B/D30-281[»]
    3OMNX-ray2.15B/D30-281[»]
    ProteinModelPortaliQ3J5G0.
    SMRiQ3J5G0. Positions 30-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3J5G0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    KOiK02275.
    OMAiDHALMIV.
    OrthoDBiEOG68SVXT.
    PhylomeDBiQ3J5G0.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3J5G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV    50
    ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL 100
    EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP 150
    DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV 200
    PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG 250
    QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV 300
    SVE 303
    Length:303
    Mass (Da):32,931
    Last modified:November 8, 2005 - v1
    Checksum:i2F363ADA39EFEBF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA77974.1.
    RefSeqiYP_351875.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA77974; ABA77974; RSP_1826.
    GeneIDi3719073.
    KEGGirsp:RSP_1826.
    PATRICi23150624. VBIRhoSph57909_0712.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA77974.1 .
    RefSeqi YP_351875.1. NC_007493.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OM3 X-ray 2.60 B/D 30-281 [» ]
    3OMA X-ray 2.30 B/D 30-281 [» ]
    3OMI X-ray 2.15 B/D 30-281 [» ]
    3OMN X-ray 2.15 B/D 30-281 [» ]
    ProteinModelPortali Q3J5G0.
    SMRi Q3J5G0. Positions 30-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_1826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA77974 ; ABA77974 ; RSP_1826 .
    GeneIDi 3719073.
    KEGGi rsp:RSP_1826.
    PATRICi 23150624. VBIRhoSph57909_0712.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    KOi K02275.
    OMAi DHALMIV.
    OrthoDBi EOG68SVXT.
    PhylomeDBi Q3J5G0.

    Enzyme and pathway databases

    BioCyci RSPH272943:GJAS-419-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q3J5G0.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158Imported.
    2. "Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump."
      Liu J., Qin L., Ferguson-Miller S.
      Proc. Natl. Acad. Sci. U.S.A. 108:1284-1289(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 30-281 IN COMPLEX WITH COPPER.

    Entry informationi

    Entry nameiQ3J5G0_RHOS4
    AccessioniPrimary (citable) accession number: Q3J5G0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3