Q3J5G0 (Q3J5G0_RHOS4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2 RuleBase RU004024
EC=1.9.3.1 RuleBase RU004024

Gene names

Name:	coxII EMBL ABA77974.1
Ordered Locus Names:	RHOS4_04060
ORF Names:	RSP_1826 EMBL ABA77974.1

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Reference proteome] [HAMAP] EMBL ABA77974.1

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity. RuleBase RU004024
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. RuleBase RU004024
Cofactor	Copper A By similarity. RuleBase RU004024
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain RuleBase RU003381 Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003381
Ligand	Copper RuleBase RU004024 PDB 3OMA PDB 3OMI Metal-binding RuleBase RU004024 PDB 3OMA PDB 3OMI PDB 3OMN PDB 3OM3
Molecular function	Oxidoreductase RuleBase RU000456 EMBL ABA77974.1
Technical term	3D-structure PDB 3OMA PDB 3OMI PDB 3OMN PDB 3OM3 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	252	1	Copper PDB 3OMA PDB 3OMI
	Metal binding	254	1	Copper; via carbonyl oxygen PDB 3OMA PDB 3OMI
	Metal binding	256	1	Copper PDB 3OMA PDB 3OMI
	Metal binding	260	1	Copper; via pros nitrogen PDB 3OMA PDB 3OMI

Sequences

	Sequence		Length	Mass (Da)
	Q3J5G0 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 2F363ADA39EFEBF8	FASTA	303	32,931
	10 20 30 40 50 60 MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV ATQIHWLDGF 70 80 90 100 110 120 ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL EIAWTIVPIV ILVAIGAFSL 130 140 150 160 170 180 PVLFNQQEIP EADVTVKVTG YQWYWGYEYP DEEISFESYM IGSPATGGDN RMSPEVEQQL 190 200 210 220 230 240 IEAGYSRDEF LLATDTAMVV PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF 250 260 270 280 290 300 RAEREGIFFG QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV SVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.
[2]	"Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump." Liu J., Qin L., Ferguson-Miller S. Proc. Natl. Acad. Sci. U.S.A. 108:1284-1289(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 30-281 IN COMPLEX WITH COPPER.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000143 Genomic DNA. Translation: ABA77974.1.

RefSeq

YP_351875.1. NC_007493.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3OM3	X-ray	2.60	B/D	30-281	[»]
3OMA	X-ray	2.30	B/D	30-281	[»]
3OMI	X-ray	2.15	B/D	30-281	[»]
3OMN	X-ray	2.15	B/D	30-281	[»]

ProteinModelPortal

Q3J5G0.

SMR

Q3J5G0. Positions 30-289.

ModBase

Search...

Protein-protein interaction databases

STRING

272943.RSP_1826.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3719073.

KEGG

rsp:RSP_1826.

PATRIC

23150624. VBIRhoSph57909_0712.

Phylogenomic databases

eggNOG

COG1622.

HOGENOM

HOG000264988.

KO

K02275.

OMA

LIEVAWT.

ProtClustDB

CLSK934044.

Enzyme and pathway databases

BioCyc

RSPH272943:GJAS-419-MONOMER.

Family and domain databases

Gene3D

1.10.287.90. 1 hit.
2.60.40.420. 2 hits.

InterPro

IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]

Pfam

PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]

SUPFAM

SSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.

TIGRFAMs

TIGR02866. CoxB. 1 hit.

PROSITE

PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q3J5G0.

Entry information

Entry name

Q3J5G0_RHOS4

Accession

Primary (citable) accession number: Q3J5G0

Entry history

Integrated into UniProtKB/TrEMBL:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)